NOTICIAS DIARIAS

New Antibiotic Battle Against Drug-resistant Superbugs

Microbiology

A new antibiotic hailed as the "last line of defense" in the battle against drug-resistant superbugs such as MSRA and VRE is taking the next step in development thanks to a UK Government grant of almost £ 500,000.

Over the next year scientists will develop a catalog of simplified synthetic versions of a naturally occurring antibiotic called teixobactin – dubbed a "game changer" when it was discovered in 2015 due to its ability to kill drug-resistant pathogens – by replacing key amino acids at specific points in the antibiotic's structure to make it easier to recreate.

The creation of an arsenal of new synthetic teixobactin molecules is a vital step in drug development due to a high failure rate when scientists only have a limited number of molecules to work with, and will form one of the key stages of the new research project.

Dr Singh, an expert in biological chemistry and specialist in novel drug design and development at the University of Lincoln's School of Pharmacy, said: "We know that the therapeutic potential of simplified synthetic teixobactin is immense, and our ultimate goal is to have a number of viable drugs from our synthetic teixobactin platform which can be used as a last line of defense against superbugs in hospitals.

"So far we have demonstrated that we can make synthetic versions which are as potent at treating drug-resistant pathogens as the real thing, but we need to expand our catalog of synthetic teixobactin as a precursor to production on a commercial scale. development, there is a very high failure rate and pinning all hopes on one molecule could be risky The catalog of molecules we will develop can be through trials with the ultimate goal of taking a drug fit for human use to the clinic. "

Antimicrobial resistance 

The work builds on the success of Dr. Singh's pioneering research to tackle antimicrobial resistance over the past three years. Earlier this year, the research team was the first in the world to successfully create simplified, synthetic forms of teixobactin. One of these was successfully used to treat bacterial infection in mice. Importantly, the synthetic teixobactin offered dual benefits of both clearing the bacterial infection and minimizing its severity, which was not the case for the clinically-used antibiotic, moxifloxacin, used as a control study. 

Dr Singh's pioneering research to tackle antimicrobial resistance over the past three years. Earlier this year, the research team were the first in the world to successfully create simplified, synthetic forms of teixobactin. One of these was successfully used to treat a bacterial infection in mice. Importantly, the synthetic teixobactin offered dual benefits of both clearing the bacterial infection and minimizing its severity, which was not the case for the clinically-used antibiotic, moxifloxacin, used as a control study.

Professor William Hope and Dr Shampa Das from the Center for Antimicrobial Pharmacodynamics at the University of Liverpool will undertake the in vivo evaluations. Professor Hope said: "We are delighted to collaborate with Dr Singh and the University of Lincoln to help develop new antibiotics that address the need for antimicrobial resistance, the teixobactin project complements our other programs for the development of new antibiotics for multidrug-resistant bacterial and fungal diseases.

Development of new antibiotics 

"Dr Shampa Das from the Centre for Antimicrobial Pharmacodynamics at the University of Liverpool will undertake the in vivo evaluations. Professor Hope said: "We are delighted to collaborate with Dr Singh and the University of Lincoln to help develop new antibiotics that address unmet medical need related to antimicrobial resistance. The teixobactin project complements our other programs for development of new antibiotics for multidrug-resistant bacterial and fungal diseases."

The next step in the research will be the production of a so-called 'investigational drug or medicine' – a drug which is developed for safe testing in humans followed by clinical trials and new drug approval by regulatory bodies.