The oral delivery of antigens for vaccination is an attractive idea for scientists mainly because they are non-invasive in nature,safe, and painless in infants. Plus, oral delivery is cost-effective; but making it a good proposition in immunization. Nanotechnology-based compounds are now being testing as a possible delivery vehicle for vaccines.
The study showing that the nanotechnology based delivery system; which are particles containing silica and the HBsAg; but the hepatitis B surface antigen; reach the intestines without being destroying by the stomach’s acidity. The study could pave the way to develop new vaccines and delivery modes that are safe and non-invasive.
Nanotechnology based deliver
Hepatitis B is a vaccine that helping protect the body against Hepatitis B, which is causing by a virus. It can lead to liver inflammation, and in the long run, can cause scarring of the organ, liver failure, and cancer. The virus can be acquiring through exposure to blood, semen and other body fluids.
A mother can also pass down the virus to her children through pregnancy. The hepatitis B vaccine is usually giving through intramuscular injection upon birth, at least one month after the initial shot; and at least 2 months after the 2nd shot. Booster doses are given every five years.
Oral formulation in nanostructure
The hepatitis B oral formulation in the nanostructure silica SBA-15; can be an effective mode to deliver the oral vaccine. The SBA-15 silica and antigen were submitted to various types of X-ray imaging in European laboratories. the researchers studying how 22 nanometers sized antigen binds to silica nanotubes with a diameter of about 10 nanometers; and a honeycomb-like structure. One nanometer, abbreviating as 1 nm, is a billionth of a meter.
However, the results obtained with HBsAg encapsulating antigen are the first to demonstrate how SBA-15 protects the antigen for oral administration of the hepatitis B vaccine. Encapsulated vaccines combine the advantages of immunization with the ease of administration by the oral route and concomitant induction of the immune response; the researchers concluded in the study.