Researchers Identify How Liver Cells: Protect Against Viral Attacks
Current models of cell-intrinsic immunity to RNA viruses centre on virus-triggered inducible antiviral responses; initiated by RIG-I-like receptors or Toll-like receptors that sense pathogen-associated molecular patterns; and signal downstream through interferon regulatory factors (IRFs); transcription factors that induce synthesis of type I and type III interferons. RNA viruses have evolved sophisticated strategies to disrupt these…