Human DNA Helps Viruses Cause Cancer

The researchers discovering that viruses can exploit the body’s DNA ;dampening its antiviral immune response and allowing infection to take hold more easily. But in some cancer Research UK-funded scientists have discovered that stretches of human DNA act as a traitor to the body’s defenses by helping viruses infect people and trigger cancer-causing diseases; per a study published in Nature Cell Biology today.

But in some studies scientists funded by Cancer Research UK and the Medical Research Council at the Cancer Institute showed this happened with the Kaposi sarcoma herpes virus; which causes the cancer Kaposi Sarcoma and with the herpes simplex virus which causes cold sores.

Multiple Ways To Prevent Or Clear Infection

Our immune system uses multiple ways to prevent or clear infection. But in some parallel, viruses have also evolved highly sophisticated counter measures to escape from the human immune defense. The team has discovered that viruses exploit tiny molecules derived from human DNA called microRNAs; to make cells more susceptible to viral infection.

But in some microRNAs are mostly found in parts of the human genome; which do not generate proteins – initially  known’junk DNA’. Lead author, Cancer Research UK’s professor of cancer medicine at UCL, Chris Boshoff, said: “We are investigating microRNAs as future therapeutic targets; and targeting cellular microRNAs could be a potential way to prevent or treat cancer-causing infection from viruses.

But in the research study author, Dr Dimitris Lagos; based at the Cancer Research UK Viral Oncology Laboratory at UCL’s Cancer Institute; said;The viruses we tested have evolved with humans for millions of years and use a variety of biological tricks to establish life-long and mostly harmless infections.

Molecules Present In Everyone’s DNA

However this study stating that it is likely that other viruses ;But in some cases which can cause diseases including cancer exploit the tiny molecules present in everyone’s DNA – called microRNA ;to turn cells into a viral ‘hotel’ which they can check into; to cause infection and spread Lesley Walker; director of cancer information, said;But this is intriguing research which unravels an ancient molecular mystery – and providing a hot new therapeutic target to prevent cancer-causing infection from viruses.

Infectious viruses and human DNA have been around for so long that a relationship has developed and viruses can cheekily use the bits of our DNA that we often think of as rubbish for their own benefit. Now we know how they are using our DNA we can research ways to put the brakes on it.