AIDS is a condition in humans in which progressive failure of the immune system; allowing life-threatening opportunistic infections and cancers to thrive. The human immunodeficiency viruses (HIV) are two species of Lentivirus; that causing HIV infection and over time acquired immunodeficiency syndrome (AIDS).
The grant from NIH’s National Institute of Allergy and Infectious Diseases puts into action knowledge gained from research under a previous seven-year grant; Burton said. A series of shots is envisioning to “train” the immune system how to make powerful antibodies; that neutralize a broad range of HIV strains. The complete sequence will probably take around nine months to deliver, with doses spaced a few months apart.
Immunodeficiency viruses vaccine
However, the precise timing will be working out as each stage of the vaccine is giving; and the immune response assessing. Studies examined if the sequential immunization approach worked in animals. Those studies were led by Bill Schief at Scripps Research and other colleagues in and outside of Scripps Research. The approach succeeded.
But broadly neutralizing antibodies were discovering from the blood of those with HIV. But these antibodies typically take years for the immune system to learn how to make. By that time, HIV is too well established for the body to eradicate. The multistage vaccine is intended to compress this immune education process into several months, Burton said. It’s not yet known how long the process will take, or how many stages.
But the study finding it was possible in most people; but that these cells requiring further exposure to HIV-related immune stimulants to mature them. The multistage vaccine is intending to produce this result. A series of shots is envisioning to “train” the immune system how to make powerful antibodies that neutralize a broad range of HIV strains.
But it will fund development and testing of a multistage preventive vaccine. The work will be performing by the Consortium for HIV/AIDS Vaccine Development, or CHAVD; an international collaboration. The multistage vaccine is intending to produce this result. They’re one of the best in the world; so that’s one of the reasons why I feel cautiously optimistic that we’ll get there.