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Prostate Cancer Targets Blocked by Nuclear Gatekeeper

Certain molecular drivers of cancer growth are "undruggable—it's been nearly impossible to develop chemicals that would block their action and prevent cancer growth. Many of these molecules function by passing cancer-promoting information through a gate in the nucleus, where the instructions are carried out.

Researchers at the Sidney Kimmel Cancer Center—Jefferson Health have found a way to block the nuclear gates used by these molecules, and show that this inhibition can halt aggressive prostate cancer in mice bearing human tumors.