In the present retrospective study, scientists explained that higher PIRADS scores are associated with a higher likelihood of the diagnosis of prostate cancer

The Prostate Imaging Reporting and Data System (PIRADS) score classify MRI lesions on a scale from 1 to 5, which reflects their level of suspicion from least to most. PIRADS 3 lesions are considered equivocal.

Dr. Niranjan J. Sathianathen and colleagues from the University of Minnesota, in Minneapolis, investigated the correlation between PIRADS 3-5 scores and the diagnosis of clinically significant and all prostate cancer for three common biopsy indications: biopsy-naive patients, patients with previous negative transrectal ultrasound (TRUS) biopsy, and active-surveillance patients.

PIRADS score

Prostate cancer of any grade was found in 51.9%, 26.5% and 43.8% of patients, respectively. Overall cancer-detection rates were 7.7% for PIRADS scores 1-2, 29.7% for PIRADS 3, 42.3% for PIRADS 4 and 82.4% for PIRADS 5, the team reports in Prostate Cancer and Prostatic Diseases, online July 23.

The detection rate for clinically significant cancers was 30.1% among biopsy-naive men, 15.7% among those with a previous negative biopsy and 19.5% among those on active surveillance.

Clinically significant cancers were found in 0% of men with PIRADS scores between 1 and 2, in 8.9% of those with a PIRADS score of 3, in 21.4% of those with a PIRADS score of 4 and in 62.7% of men with a PIRADS score of 5.

The accuracy of PIRADS scores (as measured by area under the receiver operator curves) was 0.69 for the diagnosis of any cancer and 0.74 for the diagnosis of clinically significant cancer.

Men who had a previous negative biopsy had lower detection rates for any prostate cancer for PIRADS 3 and 4 lesions compared with men who were biopsy naive or on active surveillance.

"Overall and clinically significant cancer detection rates are correlated with PIRADS score on multiparametric MRI," the researchers conclude. "Biopsy yield is also dependent on the clinical setting and this should be considered in the decision-making process when determining the need for biopsy."

"Moreover, it is important for institutions to audit their own cancer detection rates due to the multiple confounders which impact cancer detection rates," they add. "Avoiding biopsy of PIRADS 3 lesions appears to be safest in men with prior negative biopsy as it risks missing diagnosis of the fewest significant cancers."