As we know malaria is caused by a parasite. This study estimating that malaria without protection during pregnancy; 45% of 32 million pregnancies in malaria endemic sub-Saharan Africa are exposed to Plasmodium falciparum malaria; leading to 900,000 malaria associated low birth weight deliveries. Low birth weight, anaemia and other serious adverse birth outcomes result in numerous longer term health issues for infants.
This research determining most comprehensive study the impact of sulphadoxine pyrimethamine (SP) drug resistance on the effectiveness of intermittent preventative treatment (IPTp); Study review of drug-based strategies used to prevent malaria infections in pregnant women, in areas where there is widespread resistance to existing antimalarial medicines.
Impact Of Sulphadoxine-Pyrimethamine
But as per world health organization, intermittent preventive treatment (IPTp) in malaria endemic areas. The only antimalarial currently recommended for IPTp is SP; to date IPTp with SP has effectively resulted in reductions in maternal anaemia, low birth weight and neonatal mortality. However, with the growing threat of drug resistance emerging or spreading in sub-Saharan Africa, this protection is now at risk.
The study on molecular monitoring of parasites in humans is a valuable tool for policy makers to monitor the spread of antimalarial resistance and assess the impact on this valuable prevention strategy for malaria in pregnancy and therewith on the lives of newborns in low income settings across Africa.
Effective Antimalarial Prevention
This study reporting by examining the risks; outcomes and alternative strategies available we will ensure that vulnerable babies born in low resource settings are given the best possible chance of good health; by receiving the most effective antimalarial prevention approaches and medicines available to us today, and in the future.”
However, the resistance evolves by a series of mutations in the parasite;but some molecular monitoring of parasites in humans can support policy makers and health professionals to make important decisions about the need for alternative prevention options.
Immune Modulating Effects
But for example, through its anti-microbial effects; or perhaps SP has some anti-inflammatory and immune modulating effects that are like those discovering for widely used antibiotic cotrimoxazole. This is important as SP may not work as well as other antimalarial in high SP resistance areas; but it may still be able to help reduce poor birth outcomes; such as low birth weight through these other mechanisms.
The increasing prevalence of molecular markers of SP is correlating with a decrease in effectiveness of SP to reduce low birth weight and malaria infections;The results demonstrating that the clinical effectiveness of SP; in protection of pregnant women against malaria is compromising in certain areas.