Older adults have an increased risk for dementia after concussion, which is modestly reduce among patients using a statin in Seniors according to a study publish online May 20 in JAMA Neurology. Donald A. Redelmeier, M.D., from the University of Toronto, and colleagues examine whether statin use is associate with the risk for dementia after a concussion. Participants included 28,815 older adults diagnosed as having a concussion.
One case per six patients
Of the participants, 24.5 and 75.5% received and did not receive a statin, respectively. During a mean follow-up of 3.9 years, the researchers found that 4,727 patients subsequently develop dementia for an incidence of one case per six patients. Compare with those who did not receive a statin; so patients who receive a statin had a reduce risk for dementia (relative risk, 0.87).
Traumatic brain injury (TBI) is a major cause of death and disability in the United States; so where 1.4 million people sustain a TBI annually and 3 to 5 million are currently living with a TBI associate disability. Concussions are a common component of TBI. Severe TBI, such as events that involve a loss of consciousness; hence has receive a lot of attention; it is know that athletes who experience a high rate of these events have an increase risk of chronic traumatic encephalopathy.
Numerous studies conduct in the Veterans Affairs population suggest an association between TBI overall and a higher risk of dementia. However, some studies report no association between self report TBI and Alzheimer disease pathology, and a recent meta-analysis of 18 articles did not establish TBI as a risk factor for Alzheimer disease when most of the TBI exposures were gleaned from self-report.
Independent of cardiovascular medication
The association between concussion specifically and dementia is not well know and, to my knowledge; so the potential differences in this association by status of medication is unknown. Currently it is unknown whether an association between TBI and dementia; so may be amplified or mitigate among those taking common daily medications. The reduced risk was seen for diverse patient groups; hence was independent of cardiovascular medication use, intensify over time; which was different from the risk for subsequent depression, and was not seen among patients after an ankle sprain.
A concussion should not be interpret as a reason to stop statins; also a future randomize trial is justified,” the authors write. The long-term neurologic consequences of a concussion are substantial and merit attentions.”In this study, older adults had a substantial long-term risk of dementia after a concussion; which was associate with a modest reduction among patients receiving a statin.