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The Urgent Need for Better Management of Anemia

A large study just published in the journal Anaesthesia raises important questions about the way anemia is currently managed in surgical patients (Associations of nadir hemoglobin level and red blood cell transfusion with mortality and length of stay in surgical specialties: a retrospective cohort study). Professor Jeffery Hamdorf; Winthrop Professor of Surgical Education at The University…

Transfusion medicine

Six-Year-Old Girl Becoming Bone Marrow Donor

Little Caleb Ashby, from Barwell, Leicestershire, urgently needed a bone marrow transplant after a shortage of infection-fighting cells left him in danger of death by even a common cold. The four-month-old, who was also born with a heart defect; was left needing the vital marrow after undergoing surgery in his chest just weeks after birth. But…

Transfusion medicine

Younger Blood Donors are Needed to Keep Program

Big milestones were celebrated at the Gravenhurst Canadian Blood Services donor clinic on March 26. Elaine St. Pierre, territory manager for Barrie, Muskoka, Simcoe, Dufferin and Grey, said that although 50% of the population is eligible to donate blood, only four per cent actually do. “There is half a million people who are supplying the blood…

Transfusion medicine

Use of Breast Milk in Children Who Underwent Bone Marrow Transplant

A new pilot study compared the use of human breast milk to formula in children less than 5 years of age who underwent bone marrow transplant (BMT); measuring the levels of inflammatory and pro-inflammatory biomarkers in the stool and blood to assess inflammatory injury to the intestinal microbiome. Markers of inflammation The results, indicating that…

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Misconception on White Blood Cell Trafficking to Spleen

Spleen is our largest lymphoid organ. Its function is to eliminate outdated red blood cells and to produce antibodies against pathogens. Outdated red blood cells are eliminate in the spleen’s red pulp and antibodies are produce in the white pulp. The significance of the spleen for the production of antibodies is central; as removing the…

Transfusion medicine

Impact of Opioids on Pain and Survival in Sickle Cell Disease

New UMN research recently published Blood Advances, Kalpna Gupta, PhD, Professor of Medicine, University of Minnesota Medical School, demonstrates the impact of opioids on the survival of humanized mouse models with sickle cell disease, compared to normal mice. Sickle Cell Disease (SCD) affects millions of people throughout the world. The genetic disease worsens over time and…

Transfusion medicine

Inherited Genetic Variation Linked To Risk Of T Cell Leukemia In Children

A study led by St. Jude Children’s Research Hospital has identified a novel risk variant associated with T cell acute lymphoblastic leukemia (T-ALL). The findings appear as an advance online publication in the Journal of the National Cancer Institute. “The inherited genetics underlying this rare type of leukemia were mostly unknown prior to our study,” said…

Transfusion medicine

Cancer Patient With Stem Cell Derived Natural Killer Cells

After 10 years in remission, Derek Ruff’s cancer returned; this time as stage IV colon cancer. Despite aggressive rounds of chemotherapy, palliative radiotherapy and immunotherapy; his disease progressed. In February 2019; as part of a phase I clinical trial at Moores Cancer Center at UC San Diego Health; Ruff became the first patient in the…

Transfusion medicine

Step Towards Personalized Cancer Immunotherapy

Cells belonging to the body’s own immune system can help fight tumours. For several years now, this has allowed oncologists to use medications known as checkpoint inhibitors to encourage T cells to eliminate tumor cells. Last year the two scientists who discovered this therapeutic approach were awarded the Nobel Prize for Medicine. While doctors are…

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Human Protein Produced In CHO Cells Save Donor Blood

Alpha-1-antitrypsin is a protein produced by the liver. The protein gets secreted to the blood stream, where it circulates the body to protect the lungs. However, some people are born with genetic disorders that hinders production of this protein. These patients can suffer from decreased lung function, liver diseases and shortness of breath. In the…

Transfusion medicine

Immune Repelling Protein Prolongs Function Survival Of Human Stem-Cell

Encapsulating human stem-cell-derived beta cells in micro capsules made with a protein that repels key immune cells restored glucose metabolism in diabetic mice and protected the cells from immune system attack, preventing the buildup of inflammatory fibrotic tissue that has plagued previous trials of encapsulated beta cells. A team of Massachusetts General Hospital (MGH) investigators…

Transfusion medicine

Blood Cells The Missing Link In Post Exercise Boost

A discovery about how exercise improves brain function could be harnessed for research into ageing, and boosting learning and memory. An international team from The University of Queensland and the Dresden University of Technology has identified what triggers the boost to brain function through exercise. Dr. Tara Walker from UQ’s Queensland Brain Institute said the improvements…