Colorectal Cancer

Clinician in search of compelling evidence to convince sedentary patients without or with cancer to get away from their screens and into an exercise program, look no further. Results from one of the most diverse retrospective cohort studies to date show that a high level of cardiorespiratory fitness (CRF) can reduce the risk of lung and colorectal cancer in some individuals.

Reviewing data on participants in the Henry Ford Exercise Testing (FIT) Project in southeast Michigan from 1991 to 2009, researchers also found that participants with the highest CRF levels determine by treadmill stress testing had dramatically lower rates of all-cause mortality after a diagnosis of either lung or colorectal cancer.

Clinically obtain cardiac stress

The study, led by Catherine Handy Marshall, MD, of Johns Hopkins School of Medicine in Baltimore, Maryland, was publish online in Cancer. The results of the current study support the idea that clinically obtain; which of cardiac stress testing provides important additional information regarding cancer risk; also mortality after cancer diagnosis in a general, clinically refer population,” the authors write.

For the study, the investigators analyze data from 49,143 consecutive adults (median age, 54 years); so refer by their physicians for treadmill stress testing between 1991 and 2009. Our findings are [from] one of the first, largest, and most diverse cohorts; so to look at the impact of fitness on cancer outcomes,” said Marshall in a statement.

The authors note that CRF is a measure of peak energy expenditure; so that includes physical activity, genetics, age, and the overall functional health of organ systems. Compare with physical activity alone; so CRF is a better predictor of cardiovascular disease and all cause mortality; also improves the risk classification of cardiovascular disease when add to traditional risk factors,” they say.

Risk of colorectal cancer

Last spring, the Clinical Oncology Society of Australia (COSA) release a position paper; so on exercise recommending it be part of the standard of care for all patients with cancer. In the new study, subgroup analysis by sex and race mirror most of the study findings. However, there was no evidence that a high level of fitness; which reduce the risk of colorectal cancer in female and/or black cohort participants.

They point out that women have a lower overall incidence of colorectal; so cancer compare with men and tend to be diagnose at a later age. Also, potential confounders such as menopausal status; also the use of hormone therapy were not measure. Similarly, the investigators note that black Americans have a higher overall incidence of colon cancer; which compare to white Americans, and “were not as well represented in our high fitness group.

The cohort’s most fit participants tend to be younger and male, and to have a lower body mass index (BMI). They were also less likely to be smokers or to be taking aspirin or statins. Factors that contribute to the apparent protective effect of fitness are currently under active investigation, the investigators note. These include improve respiratory function; so decrease bowel transit time, better immune function, and reductions in systemic inflammation.