Artificial Sweeteners

Artificial Sweeteners; Originally synthesized in 1879 by Ira Remsen and Constantin Fahlberg, saccharin was the first artificial sweetener discovered. Fast forward to today and the artificial sweetener industry is booming with annual revenues exceeding $2 billion and numerous artificial sweeteners on the market in both food and drink products. Around 40 percent of adults and 25 percent of children have report consuming artificial sweeteners on any given day.

While these intensely sweet compounds are generally consider safe; they still know very little about their impact on pregnant women and their babies. With the prevalence of artificial sweetener consumption during pregnancy nearing one in four women, we need to better understand the impact of these compounds on infants.

Artificial sweeteners during pregnancy

Research has indicate the consumption of artificial sweeteners during pregnancy can increase the body weight of offspring, putting them at risk of obesity relate complications later in life. Another report has suggest the consumption of artificially sweeten food during pregnancy could increase a child’s risk for developing asthma; but it is unclear how or why this may occur.

To better understand the cause-effect relationship between artificial sweetener; which exposure during pregnancy and lung health in children; they turn to a novel animal model develop in the lab of Andrew Halayko; (Canada Research Chair in Chronic Lung Disease Pathobiology and Treatment Physiology) lab at the Max Rady College of Medicine; so with funding from the Banting Postdoctoral Fellowship and Developmental Origins of Chronic Disease in Children Network (DEVOTION).

With this model, we can assess how consuming artificial sweeteners; so like aspartame or sucralose, during pregnancy changes the sensitivity of the offspring to common allergens in asthma. They can also determine if exposure during pregnancy or breastfeeding is more important for asthma risk; also therefore, allow us to develop preventative strategies to limit new cases of asthma.

Incidence of asthma

This model can be applied to other environmental exposures (marijuana, air pollution, dust) thought to increase a child’s risk for asthma in order to gain a better understanding of the origins of asthma; also allow us to develop strategies aimed at decreasing the incidence of asthma in Canada.

I chose to come to the U of M and the Children’s Hospital Research Institute of Manitoba (an affiliated research partner of the university); so for my post doctoral training because the institute; so has a strong group of lung researchers that are renowned for their training and mentoring skills. Securing the prestigious Banting Postdoctoral Fellowship; which is a testament to the impactful mentorship and guidance I have received in my time at the university.

It is my desire to continue researching treatment options for lung disease that are based on the natural history of the disease and to eventually prevent lung disease in people by understanding its origins. This way, they may one day see a world in which young children are not hinder in their daily activities by a difficulty to breath.