A clinical trial testing the toxicity of a KRAS inhibitor demonstrated early promising antitumor activity and few adverse side effects in patients with advanced non-small cell lung cancer harboring KRAS G12C mutation, according to research presented today at the IASLC 2019 World Conference on Lung Cancer, host by the International Association for the Study of…
Immune checkpoint inhibitors are a type of therapy that uses the immune system to fight cancer. They have been hailed as game changing, garnering a Nobel Prize last year and quickly becoming the standard of care for many tumor types such as melanoma and certain lung and head and neck cancers. But among patients with…
The combination of low-dose, weight base ipilimumab and flat-dose nivolumab demonstrate safety and efficacy as first-line treatment for patients with stage IV non-small cell lung cancer and comorbidities that traditionally preclude them from enrolling in clinical trials, according to results of the single-arm, nonrandomize CheckMate 817 study presented at International Association for the Study of…
In this study the federal health investigators are focusing on illicit THC compounds as they search for the cause of a rash of vaping related respiratory illnesses that struck teens and young adults this summer. Health officials have interviewed eight of 15 patients in Minnesota who have been hospitalized for severe respiratory illnesses with confirmed…
Kentucky has the highest rate of lung cancer in the country, and is the leading cause of cancer related death in the United States. It claims more lives each year than breast; prostate and colorectal cancers combined. With early detection, lung cancer is very treatable, and lung cancer screening throughout the state have help detect…
Drugs called tyrosine kinase inhibitors can help certain patients with advance lung cancer live longer and better. But high out-of-pocket costs might stand in the way, a preliminary study suggests. Researchers find that of 106 patients who start tyrosine kinase inhibitors (TKIs) for advance lung cancer; one quarter with the highest out of pocket costs…
Scientists have shown exactly how mutations in two different genes coordinate to drive the development of malignant lung tumors, according to a new report in the open-access journal eLife. The study in novel genetically engineered mice look at the characteristics of lung tumors from when they are invisibly small to when they are larger and potentially…
Lung Damage; In this study researchers at the Stanford University School of Medicine have find that inflammation in the lungs, trigger by something as simple as the flu, may wake up a silent genetic defect that causes sudden onset cases of pulmonary hypertension, a deadly form of high blood pressure in the lungs. “It’s a…
Lung transplantation can prolong the lives of patients with end-stage lung disease, but the median survival rate after lung transplant is less than six years, which has improved only slightly in recent decades. To see what might help lung transplant recipients live longer, researchers at the University of Maryland School of Medicine (UMSOM) developed a…
Patients with non-small cell lung cancer (NSCLC) now have more improved treatment options compare to standard of care with the addition of several new agents called immune checkpoint inhibitors (ICI). Despite these changes, many patients still develop progressive disease after ICI treatment. In a new study publish in Clinical Cancer Research; Moffitt Cancer Center researchers describe…
Lung Damage; Drs. Donna Senger, Ph.D., Paul Kubes, Ph.D., and Stephen Robbins, Ph.D. have discovered a new way to stop harmful inflammation in the lungs due to sepsis and injury. “This work demonstrates the power of collaboration in solving complex health issues to benefit patients,” says Robbins, a professor in the departments of Oncology, and…
Lung cancer screening has been widely endorsed by the U.S. medical community as an effective way to save lives by detecting lung cancer at earlier, more treatable stages. A new study by researchers at National Jewish Health indicates that the low-dose CT scans used in lung cancer screening can also provide valuable information to detect…