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Exercise positively impacts mood and symptoms of depression; however, the mechanisms underlying these effects are not fully understood. Recent evidence highlights a potential role for skeletal muscle-derived transcription factors to influence Trp metabolism, along the kynurenine pathway; which has important implications in depression. This has important consequences for older adults; whose age-related muscle deterioration may influence this pathway; and may increase their risk for depression. The benefits of exercise are widely known; but kinesiologists at McMaster University have for the first time found that physical activity may help fight depression in seniors; by stimulating muscle-generated mood boosters.

The use of exercise as a treatment

The findings, published in the American Journal of Physiology — Cell Physiology; reveal that the underlying mechanisms which make us feel good; when we exercise persist into old age and highlight the importance of staying active. “A previous study demonstrated these mechanisms in healthy young adults; however, it was unknown whether the muscle deterioration; which accompanies aging would preclude older adults from achieving similar exercise-induced benefits;” explains David Allison.”This could have important implications concerning the use of exercise as a treatment; or a preventative strategy for depression in seniors;” he says.

Little is known about the relationship between skeletal muscle and mental health; or how exercise impacts this relationship. Earlier research has shown that physical activity may help to ‘turn on’ genes within skeletal muscle;  which can then influence the key metabolic pathways that ultimately promote mood-enhancing chemicals; such as serotonin, within the brain. Muscle loss is a common problem in the elderly which may restrict; that pathway and therefore increase the risk for depression; says Allison. For the study, a group of healthy men, aged 65 and over; followed a 12-week protocol of high-intensity interval training (HIIT) on a stationary bike once a week combined with bi-weekly strength training sessions.

Exercise among the clinically depressed

So, researchers analyzed blood samples and changes to muscle and determined that; three months of exercise was enough to enhance gene expression within the skeletal muscle.”Even individuals who are already metabolically healthy — with good weight, good blood pressure and blood sugar levels — need to prioritize regular physical activity to maintain or improve upon their mental health,” says Allison in conclusion. “We have shown such benefits are still achievable in old age and further emphasize the importance of maintaining an active lifestyle.”In the future, researchers hope to explore the relationship between mental health and exercise among the clinically depressed to see if similar biochemical changes can have the achievement.