All news from Rheumatology

Osteoarthritis of the knee

Stem Cells: Effective Relief From Arthritic Knees

Stem cells collected from the patient’s own bone marrow holds great interest as a potential therapy for osteoarthritis of the knee (KOA) because of their ability to regenerate the damaged cartilage. The results released today in STEM CELLS Translational Medicine (SCTM). KOA is a common, debilitating disease of the aging population in which the cartilage wears…

Drug-Related Problems

Drug-Related Problems In Patients With Rheumatoid Arthritis

RA may lead to multiple complications and comorbidities; such as cardiovascular, pulmonary, and neuropsychiatric diseases, infection, and malignancy. The risk of cardiovascular disease is higher by 1.5-fold to 2-fold in RA patients, due to systemic chronic inflammation of RA. According to a previous study, RA patients have two or more comorbidities on average. A recent nationwide…

Synovial Tissue Biopsy

Rheumatoid Arthritis: Synovial Tissue Biopsy Analysis

Rheumatoid arthritis (RA) is a heterogeneous disease in its clinical manifestations and bio-molecular pathology. The fact that not all patients are the same makes predicting disease onset, progression, and severity; response to treatment extremely challenging. Despite several attempts to identify blood-based biomarkers to guide clinical decision-making such as treatment choices, these have generally proven too…

Global health impact of RA

Investigate The Global Public Interest In Rheumatoid Arthritis

In recent years, biological agents are prescribed targeting RA pathophysiology; these treatments have shown a beneficial effect in alleviating symptoms and improving disease outcome. The progress in therapeutic strategies and monitoring are helpful for the patients to achieve early and sustained clinical remission. However, both direct and indirect high cost of treatment creates a heavy…

Disability in arthritis

Interplay Between Pain And Disability In Arthritis

To examine the interplay between pain and disability in arthritis when adjusting for patient heterogeneity in pain progression. There is consistent evidence to suggest that people experience osteoarthritis heterogeneously; with subgroups of people having different trajectories of pain. However, at present, it is unclear how these pain trajectories are related to functional disability. Secondary analysis of a…

Rheumatoid arthritis

MRI Score: The Validity Of The Rheumatoid Arthritis

In rheumatoid arthritis (RA), conventional radiographs are traditionally using to assess structural damage as an outcome measure for the efficacy of treatment in trials. However, radiographs do not assess disease activity, and with improving treatment strategies, structural damage has become less common. Therefore, in recent years MRI is increasingly in studies; as it detects damage…

Inflammatory arthritis

Sexual Function: Inflammatory Arthritis May Impact Intimacy

A systematic review and analysis of published studies found consistent links between inflammatory arthritis and impacts on intimacy and sexual function for both men and women. The Arthritis Care & Research analysis included 55 studies. People living with inflammatory arthritis demonstrated a higher prevalence of sexual dysfunction compared with other individuals. For both genders, disease-related factors including…

Step therapy position

New Drug: Pricing And Step Therapy Position Statements

Step therapy, or fail first, is a process that requires individuals who have prescribed certain medications to try and fail one or more medications preferred by the insurer before receiving the originally prescribed drug. There is no “one size fits all” treatment option for epilepsy; the response to epilepsy medications can differ for each person.…

Radiographic analysis

Radiologic Data Suboptimal In Rheumatoid Arthritis

Data published in Seminars in Arthritis and Rheumatism show significant heterogeneity in the strategy used to analyze radiographic progression in recent clinical trials and observational studies of rheumatoid arthritis (RA); with the majority of the analyses applying simple, suboptimal, or inappropriate methods. The distribution of progression scores in RA is highly and thus requires the use…

knee pain

Evaluation Can Determine Cause, Guide Treatment For Knee

It’s possible that your knee pain could traced back to your fall. You may have injured your knees without realizing it when you fell, or the trauma of the fall could have caused your arthritis to flare. Either way, you should make an appointment to have your condition evaluated. That evaluation will guide treatment going…

Development of osteoarthritis

Using Gene Therapy Strategies To Treat Osteoarthritis

In the medicine field gene therapy (also called human gene transfer) is the therapeutic delivery of nucleic acid into a patient’s cells as a drug to treat disease. The first attempt at modifying human DNA was performed in 1980 by Martin Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of Health, was performed in May 1989. Osteoarthritis (OA)…

Spondyloarthritis

FDA Approves Treatment For Axial Spondyloarthritis

The U.S. Food and Drug Administration today approved Cimzia (certolizumab pegol) injection for treatment of adults with a certain type of inflammatory arthritis called non-radiographic axial spondyloarthritis (nr-axSpA), with objective signs of inflammation. This is the first time that the FDA has approved a treatment for nr-axSpA. Approval of Cimzia fulfills an unmet need for…