All news from Rheumatology

Juvenile idiopathic arthritis

Guidelines On Juvenile Idiopathic Arthritis

The American College of Rheumatology (ACR), in partnership with the Arthritis Foundation (AF), released two guidelines on juvenile idiopathic arthritis (JIA). One guideline aims to provide therapeutic approaches for non-systemic polyarthritis, sacroiliitis, and enthesitis; and the other focuses on the screening, monitoring and treatment of JIA with associated uveitis. Juvenile arthritis (JA) is a common,…

Ankylosing spondylitis

Differentiation Of Mesenchymal Stem Cells In Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a common autoimmune disease that affects the axial skeleton; one of its critical pathogenic features is new bone formation at local sites of entheses; which is confined to the periosteal bone compartment, outside the cortical bone lining. In recent years, many researchers have investigated the mechanism of pathological osteogenesis in AS. However,…

Inflammatory

Pathogenesis And Novel Therapeutics In Arthritis

Arthritis has a high prevalence globally and includes over 100 types; the most common of which are rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis and inflammatory arthritis. All types of arthritis share common features of the disease, including monocyte infiltration, inflammation, synovial swelling, pannus formation; stiffness in the joints and articular cartilage destruction. The exact…

Protein antibodies

Preferences and Predicted Uptake Of Preventive Treatments

Anti-citrullinated protein antibodies (ACPA); that accumulate during an “at-risk” pre-clinical phase. This pre-clinical phase lasts 3–5 years before culminating in clinical disease and can describe in five phases. Asymptomatic phases (A-C) depend on whether individuals have genetic (Phase A) or environmental (Phase B) risk factors; or systemic autoimmunity associated with RA (Phase C). In Phase…

Rheumatologists

Rheumatologists Made Little Gain In Salary This Year

Rheumatology is a branch of medicine to the diagnosis and therapy of rheumatic diseases. Physicians who have undergone formal training in rheumatology are rheumatologists. Therefore rheumatologists deal mainly with immune-mediated disorders of the musculoskeletal system, soft tissues, autoimmune diseases, vasculitides, and heritable connective tissue disorders. Hence many of these diseases are now to disorders of the immune system.…

Synovial joints

Sustained Remission In Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that affects synovial joints. The pathology of the disease process often leads to serious functional disability and chronic pain caused by the destruction of the joint. Previous studies have reported that intensive management of RA improves radiographic disease progression, physical function; quality of life. Hence, remission…

Psoriasis Arthritis

Risk Scores In People With Rheumatoid Arthritis and Psoriasis Arthritis

Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are two of the most prevalent rheumatic diseases which have an impact on the health system. Among the repercussions of these diseases, their relationship with an increase in cardiovascular disease (CVD); morbidity, and mortality stands out, owing to the role played by inflammation in both pathologies. Thus, it…

Anti-inflammatory drugs

Systemic And Intra-Articular Treatments Against Rheumatoid Arthritis

Despite the wide range of available treatments, rheumatoid arthritis (RA) continues to pose a substantial burden across the globe; with unmet needs in key domains, such as pain, physical and mental functions, and fatigue. The conventional strategy of medical therapy for RA involves the nonsteroidal anti-inflammatory drugs (NSAIDs), but the side effect and resistance of…

Joints inflammation

Role Of ανβ3 And α5β1 Integrins In Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease with joints inflammation with synovitis, pannus formation and cartilage damage. It involves extreme progressive bone resorption that often ultimately results in articular bone erosion and periarticular bone demineralization. These conditions can impair other non-joint body systems such as chest, nerves, skin and eyes. Moreover, it can also…

The vagus nerve

Vagus Nerve Stimulation Shows Treatment Of Rheumatoid Arthritis

The vagus nerve, historically cited as the pneumogastric nerve, is the tenth cranial nerve or CNX; interfaces with parasympathetic control of the heart, lungs, and digestive tract. The vagus nerves are paired but are normally referred to in the singular. It is the longest nerve of the autonomic nervous system in the human body. Upon leaving the medulla oblongata between the pyramid and the inferior cerebellar peduncle; the vagus…

Calcium pyrophosphate deposition disease

Asymptomatic To Acute Or Chronic Inflammatory Arthritis

Calcium pyrophosphate deposition disease (CPPD) is a crystal deposition arthropathy; involving the synovial and periarticular tissues. Its clinical presentation may range from being asymptomatic to acute or chronic inflammatory arthritis. Different terms are used to describe the varied phenotypes of calcium pyrophosphate deposition disease. Acute calcium pyrophosphate (CPP) deposition arthritis; frequently referred to as “pseudogout,”…

Cardiovascular benefits

Rheumatoid Arthritis Patients Likely To Experience Cardiovascular Benefits

Results from a large clinical trial indicate that patients with rheumatoid arthritis; are likely to experience the same level of cardiovascular benefits from statins as other individuals; without additional risks. Patients with rheumatoid arthritis have an approximately 50% higher risk of experiencing cardiovascular events such as heart attack and stroke compared with the general population.…