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Rheumatoid Arthritis

Upadacitinib Monotherapy Effective in Refractory Rheumatoid Arthritis

Rheumatoid Arthritis; monotherapy with the JAK1-selective inhibitor upadacitinib is effective in patients with active rheumatoid arthritis; but who have an inadequate response to methotrexate, according to results from the SELECT-MONOTHERAPY phase 3 trial. As many as two-thirds of patients with rheumatoid arthritis receiving methotrexate monotherapy fail to achieve satisfactory disease control. Oral therapy with upadacitinib…

Biosimilars

Biosimilars: British Columbia Switches Patients to Biosimilars

Biosimilars; The Canadian province of British Columbia said on Monday that its public drug plan will switch as many as 20,400 patients from three branded biologic drugs to cheap near-copies called biosimilars, saving an estimated C$96.6 million ($71.9 million)over three years. The new policy from the province’s PharmaCare program targets Johnson & Johnson’s Remicade and…

Stem Cell

Another Stem Cell Company Warned By FDA for Unapproved Treatments

Stem Cell; the US Food and Drug Association (FDA) sent an untitled letter to R3 Stem Cell LLC charging the company with significant violations of the Public Health Service Act (PHS Act) for offering unapproved therapies. Following a review of the R3 website, the FDA’s Office of Compliance and Biologics Quality; but sent the letter…

Arthritis Therapies

Expanding Arthritis Therapies Top Agenda at EULAR

Arthritis Therapies; much-needed options for the treatment of osteoarthritis will be in the spotlight at the upcoming European League Against Rheumatism (EULAR) Congress 2019. But an aging world population highlights the lack of effective osteoarthritis treatments, said John Isaacs; MBBS, PhD, from Newcastle University in Newcastle Upon Tyne; United Kingdom, who is chair of the…

Rheumatoid Arthritis

Rheumatoid Arthritis Leads To Health Issues, High Treatment Costs

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that leads to significant; but health issues as well as high treatment costs. In this themed issue of Clinical Therapeutics, experts review multiple aspects of RA detection and intervention; with the overall goal of moving the field closer to developing effective preventive measures. Identifying people before…

Different Forms Of Arthritis

Link Between Tissue Cell Type And Different Forms Of Arthritis

Arthritis; Pioneering research by scientists at the Universities of Oxford and Birmingham published; in Nature brings us a step closer to developing targeted therapies for inflammatory diseases. The research team shows, for the first time, that different types of fibroblasts—the most common cells of connective tissue in animals; are organise in different layers in the joint and…

Rheumatoid Arthritis

The Cellular Mechanisms Driving Rheumatoid Arthritis

Newly identified subsets of cell types present in joint tissue in people with rheumatoid arthritis; and how they interact may explain why only some people respond to existing medications; according to two studies by co-senior author Laura Donlin, Ph.D.; but Co-Director of the Derfner Foundation Precision Medicine Laboratory at Hospital for Special Surgery (HSS); and…

Golimumab

Golimumab Efficacy Maintained Through 1 Year In AS

Intravenous golimumab, administered in doses of 2 mg per kg, maintained its efficacy through 1 year in patients with ankylosing spondylitis, with no new safety-profile concerns, according to data published in the Journal of Rheumatology. “Shared decision making with patients can improve treatment satisfaction and is part of the treatment; discussion between patients and health care providers,”…

Rheumatoid arthritics

Need to Know About Alternatives to Surgery

The study find that the Arthritis in the knees can strike people as young as 45; with symptoms severe enough to limit activities and harm quality of life. What can be done about it First; know that inactivity isn’t the answer. You need to move, so try low-impact exercises like walking and swimming. Researchers are…

Biologics In RA

Postoperative Infection Rate Similar Across Biologics In RA

For patients with rheumatoid arthritis (RA) undergoing arthroplasty, the risk for postoperative infection is similar across biologics but is increased with glucocorticoid use, according to a study published online in the Annals of Internal Medicine. Michael D. George, M.D., from the University of Pennsylvania Perelman School of Medicine in Philadelphia; and colleagues compared the risk…

Racial/Ethnic Groups

Lupus Characteristics And Progression Differ Among Racial/Ethnic Groups

The California Lupus Surveillance Project (CLSP) is a population‐based registry of individuals; but with SLE residing in San Francisco County, California from 2007–2009; but with a special focus on Asians/Pacific Islanders (API) and Hispanics. We used retrospective CLSP data to analyze racial/ethnic differences; but in lupus manifestations and in the timing and risk of developing…

Knee Arthroplasty

Stopping bDMARDs Before RA Hip, Knee Arthroplasty Questioned

Stopping biologic disease-modifying antirheumatic drugs (bDMARDs) for patients with rheumatoid arthritis (RA); before they undergo hip or knee replacement might increase postoperative infection; risk if it leads to increased use of glucocorticoids (GCs) to control disease flares, a study suggests. Guidelines advise stopping bDMARDs before patients with RA undergo hip or knee replacement; but the…