All news from Rheumatology

Arthritis

New Arthritis Severity New Gene Identified

A new gene associated with disease severity in models of rheumatoid arthritis has identify; by researchers at the Icahn School of Medicine at Mount Sinai. The discovery could provide a new pathway for treatment; and a way to measure the prognosis of patients diagnosed with the autoimmune condition. However, through a series of experiments on…

Upadacitinib

Upadacitinib Outperforms Adalimumab In methotrexate-Refractory RA

Upadacitinib, a JAK1 inhibitor, is superior to adalimumab and placebo at improving signs, symptoms and physical function among patients with rheumatoid arthritis who have had an inadequate response to methotrexate, according to data published in Arthritis & Rheumatology. “But they have multiple medications for RA and the question now is in what order do we select them,” Roy…

Septic Arthritis

Safety Lapses Spurred Septic Arthritis Outbreak

On March 6, 2017, the New Jersey Department of Health received reports from a hospital that three patients; who had been admitted for treatment of septic arthritis; had all received intra-articular injections for osteoarthritic knee pain at the same private outpatient clinic in suburban New Jersey. The next day, the facility, identified in media reports…

Osteoarthritis

Stratification Tool Predicts Functional Disability: Risk For Osteoarthritis

Easily acquired data such as education, depression symptoms; strenuous activity and obesity can help identify functional decline risk among individuals before they develop osteoarthritis; according to a study published in the Annals of the Rheumatic Diseases. “It is very challenging for patients and their providers; to manage disability from knee OA after it has developed,”…

Rheumatoid arthritis

Cost Effectiveness Of Different Of Treatments For Rheumatoid Arthritis

A team of researchers affiliated with several institutions in Finland has created a model to compare; the cost-effectiveness of different types of treatments for rheumatoid arthritis. In their paper published in the open access journal PLOS One, the group describes; how they created their model and what it showed. Rheumatoid arthritis (RA) causes significant costs…

IBD

IBD Risk Increases With Enbrel Therapy For Rheumatoid Arthritis

Anti‐tumour necrosis factor‐alpha (anti‐TNFα) agents have revolutionised; the management of numerous chronic inflammatory diseases such as rheumatoid arthritis (RA), ankylosing spondylitis (SpA); psoriatic arthritis (PsA) and inflammatory bowel disease (IBD) among others. Patients receiving Enbrel for inflammatory diseases other than inflammatory bowel disease; have an increased risk for a diagnosis of Crohn’s disease or ulcerative…

TNF-inhibitor

TNF-Inhibitor Tapering: Standard Dose In Axial Spondyloarthritis

Mild TNF-inhibitor tapering is about as efficacious as the standard dose treatment in achieving inactive disease; in patients with axial spondyloarthritis, according to data publish in Arthritis Research & Therapy. “The efficacy of long-term TNF [inhibitor] treatment has been demonstrated by several randomized controlled trials and large cohort studies,” Eun Young Lee, MD, PhD, MS, of the…

Filgotinib

Filgotinib Improves RA Signs, Symptoms In DMARDs-Refractory Patients

“The study demonstrates that this new selective JAK1 inhibitor works well in patients; who have failed standard of care therapies,” Mark C. Genovese, MD, of the Stanford University School of Medicine. Rheumatoid arthritis patients who previously had an inadequate response to biologic DMARDs demonstrated; improved signs and symptoms after receiving daily doses of filgotinib. “The…

Osteoarthritis

Socioeconomic Factors Moderate Racial Disparities: Osteoarthritis

Although black adults with knee osteoarthritis demonstrate worse performance-based physical function than white patients, these disparities are diminished when adjusting for socioeconomic and physical health factors, according to findings publish in Arthritis Care & Research. “Physical function is a very important outcome for people with osteoarthritis; since reduced function can lead to disability and interfere…

Ultrasound Monitoring In Rheumatoid Arthritis

Swollen Joints Best For Ultrasound Monitoring In Rheumatoid Arthritis

Ultrasound monitoring among patients with rheumatoid arthritis, the hand with more clinically swollen joints is likely to be the best option for monitoring ultrasound activity, and thus best choice for unilateral scoring, according to findings publish in Arthritis Research & Therapy. “In unilateral scoring systems, the suggestion is to choose either the dominant side or…

Baricitinib

Baricitinib Improves RA In Patients Unresponsive To Methotrexate

Baricitinib monotherapy improves disease control in many patients with rheumatoid arthritis; who were did not respond to methotrexate, according to data published in Arthritis Care & Research. “Many patients and physicians prefer monotherapy treatment; for numerous reasons including cost and decreased potential toxicity,” Roy M. Fleischmann. “This post hoc analysis was designed to investigate what %…

Rheumatoid Arthritis

Disease-Modifying Antirheumatic Drugs: Patients With Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterize by synovial inflammation; which can lead to irreversible articular damage, a decrease in physical functioning, and radiologic progression. Patients are recommend to use disease-modifying antirheumatic drugs (DMARDs); to suppress the inflammatory response and to improve clinical outcomes. Nevertheless, non-adherence to these drugs is a major issue.…