NIBIB-developed researchers have developed a 3-D-printed scaffold coated aggregate, a native cartilage component, to improve the regeneration of cartilage tissue in joints. The scaffold was combined with a common microfracture procedure and tested in rabbits. University of Maryland researchers found the combination of the implant and microfracture procedure to be ten times more effective than microfracture alone. Microfracture alone is the standard therapy currently.
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Spondyloarthritis is one of the most common types of chronic joint inflammation, affecting nearly 1 to 2% of the Western population. Cytokine blockade of tumor necrosis factor (TNF), and more recently, Interleukin-17 (IL-17), has revolutionized the outcome of patients suffering from this disease by achieving high levels of therapeutic efficacy.
The big toe on Pattie Bostick-Winn's right foot was excruciatingly painful, likely the result of her 10 years as a professional dancer in Broadway-style shows. Often, she had to wear heels on the stage, and by age 48, the cartilage had worn away between the bones connecting her big toe to the ball of her foot.
Heberden's nodes (HNs) are bony enlargements of the finger joints that are readily detectable in a routine physical examination and are considered hallmarks of osteoarthritis. A new Arthritis & Rheumatology study found that the presence of HNs may also indicate structural damage associated with knee osteoarthritis.
More than 30 million Americans suffer from osteoarthritis of the knee, according to the Centers for Disease Control and Prevention. The degenerative joint disease, often caused by wear and tear, is a leading cause of disability in the U.S. Partly triggered by a breakdown in the fibrocartilage between the bones of the knee joint such as the meniscus, osteoarthritis results in pain, stiffness and less range of motion.
There is an ongoing debate regarding the relationship between knee osteoarthritis and hormone therapy (HT), with small-scale studies providing mixed results. A new large-scale study from Korea shows that women receiving HT had a significantly lower prevalence of symptomatic knee osteoarthritis compared with women who did not take hormones.
The first study to document the prevalence and structure of financial conflicts of interest (FCOI) among authors of rheumatoid arthritis (RA) randomized clinical trials (RCTs) found no overall impact of authors' FCOI or of funding source on study outcomes. The study did see, however, that tests were more likely to be positive if an author had received honoraria or consulting fees from the sponsoring drug company.
Surgeons at The Ohio State University Wexner Medical Center are the first in the U.S. to implant a new device designed to relieve knee pain and help people with osteoarthritis prevent or delay knee replacements.
A ground-breaking new study led by researchers from the Lady Davis Institute (LDI) at the Jewish General Hospital (JGH) has succeeded in compiling an atlas of genetic factors associated with estimated bone mineral density (BMD), one of the most clinically relevant factors in diagnosing osteoporosis.
The first meta-analysis of long-term pharmacologic treatments for knee osteoarthritis (OA) found little evidence that most prescribed medications improve pain control or preserve joint structure after 12 months of treatment. There was a small but statistically and clinically significant benefit from prescription-grade glucosamine sulfate .
Study data published in Rheumatology suggest that deficient disease activity may be an appropriate target for remission in patients with psoriatic arthritis (PsA) treated with golimumab.
Elderly patients with rheumatoid arthritis (RA) continuously taking methotrexate throughout 12 months showed a 20% decrease in their risk for cardiovascular events compared with patients who did not receive any methotrexate over the previous year, according to a study published in The Journal of Rheumatology.