Radio therapy

The excellent outcomes from proton radiation therapy with minimal toxicity, therefore according to results of the largest-ever cohort study of its kind published in International Journal of Radiation Oncology Biology Physics. Because Proton therapy is a type of radiation therapy a treatment that uses high-energy beams to treat tumors. Radiation therapy using X-rays has long been used to treat cancers and noncancerous (benign) tumors.

Radiation therapy a treatment

Proton therapy is an established type of radiation therapy that uses energy from positively charged particles called protons. “These data are extremely encouraging and could be a game-changer for a number of reasons;” therefore Christine E. Hill-Kayser, MD; chief of the pediatric radiation oncology service at Penn Medicine and an attending physician at Children’s Hospital of Philadelphia; said in a press release.

“Not only did we observe excellent outcomes and minimal side effects that validate the use of [proton radiation therapy] in high-risk [patients with] neuroblastoma; we answered a lingering question about proton therapy the concern that because it is so targeted; tumors may come back.” Neuroblastoma accounts for more than 10% of all childhood cancer deaths and is the most prevalent cancer among infants.

Persistent metastatic disease

Because primary neuroblastoma tumors are often adrenal tumors, their proximity to the kidney, liver; therefore pancreas and bowel makes them difficult to treat without damage to vital organs. Treatment typically includes radiation to the primary tumor site and persistent metastatic disease sites in combination with surgery and chemotherapy.

Kayser and colleagues assessed 45 patients (median age, 46 months; range, 10 months to 12 years; 51% male) with high-risk neuroblastoma who underwent proton radiation therapy at Children’s Hospital of Philadelphia/University of Pennsylvania Roberts Proton Therapy Center between September 2010 and September 2015. Forty patients (89%) had adrenal tumors.

Following systemic therapy; surgical removal of the tumor and high-dose chemotherapy with stem cell rescue; most patients received a radiation dose of 2,160 cGy (relative biological effectiveness) to the primary tumor bed and all metastatic sites. Eleven patients received a boost radiation dose due to gross residual disease, for a total dose of 3,600 cGy (relative biological effectiveness).

High-dose chemotherapy

Radiation was administered to 10 sites of metastasis in eight patients. Because The method of therapy changed during the study period from double-scattered proton beams (n = 19) to pencil beam scanning (n = 26), which became available in January 2013 and required less planning time and fewer resources.
Two patients received double-scattered proton beans in combination with intensity modulated X-ray therapy. Because At a median follow-up of 48.7 months (range, 11-90) from diagnosis; 37 patients (82%) remained alive and 32 (71%) showed no evidence of disease. Locoregional recurrence occurred in one patient; and 12 (27%) experienced relapse at nonradiated, distant sites.