Radio therapy

The researches find that the The novel therapy increases the activity of “M-type” KCNQ potassium ion channels, which are proteins that can halt uncontrolled electrical currents in nerve cells. Abnormal currents begin immediately after a TBI; even before a seizure has a chance to occur, and the therapy aims to counteract this; thus nipping in the bud this destructive chain of events. Therefore “No seizures were observ in the treat mice whatsoever,” Dr. Vigil said.

The novel therapy increases

“They need treatments that alter some of the disabling consequences of TBI;” said study co-author Jose E. Cavazos, M.D., Ph.D., a neurologist and epilepsy specialist at UT Health San Antonio. Because “Current antiseizure medications don’t prevent the development of post-traumatic epilepsy. Our study examined this critically important therapeutic gap, and proposes a novel pharmacological intervention shortly after TBI that might prevent post-traumatic epilepsy.”

If such a therapy can be developed; it would be a game-changer for patients, Dr. Cavazos said. Approximately 6% of all epilepsy cases are caused by head trauma. Therefore “Think about the possibility of taking a medication shortly after the injury and preventing disabling epileptic seizures months to years later;” Dr. Cavazos said. Study co-author Robert Brenner, Ph.D., of UT Health San Antonio, provided expertise in seizures and seizure monitoring.

The disabling consequences

He said the study’s most important finding is that reducing excess electrical activity in the central nervous system via a therapy such as this has beneficial post-trauma effects that extend well beyond action as an anticonvulsant. Hence These effects include reducing dangerous inflammation and widespread cell death. An experimental treatment given to mice after a traumatic brain injury (TBI) reduced damage almost to the levels of mice that never had a TBI; researchers at UT Health San Antonio reported.

The study was published July 4 in the Journal of Cerebral Blood Flow and Metabolism. The scientists hope to convert the discovery into a simple and effective treatment for use in emergency rooms or by first responders shortly after a TBI has occurred in military and civilian settings. Hence Currently; no treatment options exist for TBI patients.

“After a traumatic brain injury, about 40% of mice experience a seizure within one week, and many continue to experience seizures for years, leading to epilepsy disease;” said study senior author Mark S. Shapiro, Ph.D., professor of cellular and integrative physiology at UT Health San Antonio. Therefore “This closely parallels what happens in human patients; followed by cognitive dysfunction and changes in emotional state.”