Radio daignosis

The study find that the Breast cancer detection is similar with digital breast tomosynthesis (DBT) or standard digital mammography, though DBT may reduce recall rates, researchers say. therefore “They expected; based on results from other studies; a higher detection rate in the DBT-arm;” Dr. Solveig Hofvind of the Cancer Registry of Norway told Reuters Health by email. “The results were thus somewhat controversial and need explanation.

Digital breast tomosynthesis

Our study illustrates the complex interplay between new techniques and human readers in high-volume screening; and the challenges related to implementation of new technology.”  Because “Our study is perform in a real-world setting in a high-volume screening program;” she noted.

“Independent double batch reading is perform;but followed by consensus, according to the European guidelines. About half of cases were dismissed at consensus. Therefore This procedure is typical in most European countries, but differs from most screening procedures in the U.S.”

High-volume screening

Further, “the study is perform using first generation DBT equipment; and the radiologists had limit experience in screen-reading DBT when the study started, which is natural;” she said. Therefore “The order of the reading and the type of images used might have had an effect on the interpretation.”

“An extensive hanging protocol and pressure to perform efficiently might have affected the number of cases discussed, and dismissed, at consensus,” she added. “Further; findings on DBT might have been present and perceptible by radiologists on the previous digital mammogram, but considered non-suspicious or positive, but dismissed on the consensus.”

“The radiologists were blinded to the results from interim analyses – no feedback is give if the results were in line with the recommended values in BreastScreen Norway;” she added. Therefore “Experience shows that feedback to radiologists can impact their performance.” Dr. Hofvind and colleagues randomized close to 30,000 women ages 50-69 to DBT or digital mammography screening.

Previous digital mammogram

As reported online May 8 in The Lancet Oncology; after exclusions, a total of 28,749 were included in the analyses. The proportion of screen-detected breast cancers did not differ between the two groups: 0.66% in the DBT group versus 0.61% in the digital mammography group (RR 1.09). Further, after a consensus meeting, the proportion of biopsies did not differ between the groups: 1.8% for DBT versus 1.9% for digital mammography.

“Economic analyses and follow-up studies on interval and consecutive round screen-detected breast cancers are needed to better understand the effect of digital breast tomosynthesis in population-based breast cancer screening.””As the first randomized; controlled trial with digital breast tomosynthesis in a real-world; therefore population-based screening program, this study contributes to our understanding of digital breast tomosynthesis in breast screening; provides evidence-based findings on its early implementation; and has the potential to contribute valuable information on interval cancers.”