Radio daignosis

When appropriate, short-interval follow-up magnetic resonance imaging (MRI) can be used to identify early stage breast cancer and avoid unnecessary biopsies; according to a study to be present at the ARRS 2019 Annual Meeting, set for May 5-10 in Honolulu, HI. Utilization of MRI for breast cancer screening continues to increase, as it is the most sensitive modality to detect breast cancer.

Avoid unnecessary biopsies

Yet, much more is know about short-term follow-up of probably benign findings (<2% of malignancy) for mammography than MRI. The study is conduct to evaluate the frequency and cancer yield of American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) 3 lesions in patients undergoing baseline versus non-baseline high-risk screening MRI exams. Non-baseline MRI screening exams are define as those preceded by at least one screening exam.

Among the 6672 MRI screening exams perform in 3214 patients include in the study, 202 (3.0%) are assign a BI-RADS 3. Among baseline exams, 8.3% (82/983) were assigned BI-RADS 3; compared to 2.1% (120/5689) of non-baseline exams (p<0.01). 13 of 202 (6.4%) of the total BI-RADS 3 lesions yielded malignancy, with 12 of the 13 cancers described as either stage 0 or I at diagnosis.

Non-mass enhancement

Out of 82 baseline exams, the cancer yield of BI-RADS 3 was 2 (2.4%); versus 11 of 120 (9.2%) on non-baseline exams (p=0.056). Of the 13 diagnosed cancers, 8 were initially characterize as foci, 3 as non-mass enhancement; and 2 as masses. 10 of 13 cancers are upgrade at the 6-month follow-up MRI or before.

The results indicate BI-RADS 3 assessments are significantly more common in baseline versus non-baseline screening breast MRI exams, and BI-RADS 3 lesions on baseline exams have a lower cancer yield. Most cancers diagnose on follow-up of BI-RADS 3 lesions are early stage and most are diagnose at or before the 6-month follow-up.

An appropriate technique

The results indicate that when employed sensibly; short-interval follow-up MRI is an appropriate technique to identify early stage breast cancer. “This study clarifies that probably benign assessments can be as useful for MRI as they are for mammography;” said co-author Leslie Lamb, MD, MSc, of Massachusetts General Hospital (MGH) and Harvard Medical School, both in Boston.
“Many patients and providers question the utility of BI-RADS 3 in MRI; particularly as some insurers do not cover the costs of the short interval follow-up MRIs. This study clarifies that short interval follow-up MRI is a valuable method of identifying early stage breast cancer while avoiding unnecessary biopsies.” noted co-author Christine Edmonds, MD, of the department of radiology at MGH.