Researchers finding that antibodies; which unlock the body’s regenerative potential. As body making antibodies to fight the infections. But the synthetic versions of these molecules could hold the key to stimulating the body’s ability to regenerate. Antibodies are increasingly being developing into drugs to their ability to bind and affect the function of other proteins in cells.
Antibiotics they are encoding by the genes; antibodies can be creating in the lab using genome and protein engineering technologies. This developing new molecules that have never been seen before and whose potential for regenerative medicine is enormous.
The antibodies were engineered to mimic key growth factors, proteins called Wnt that normally instruct stem cells; cells that can turn into any cell type in the body to form tissue in the embryo. Wnt proteins also activate stem cells for tissue repair following injury in adults, while mistakes in Wnt signaling can lead to cancer. But these efforts were stymied by the molecules complicated chemistry Wnt proteins are attached to fat molecules, or lipids; which makes their isolation in active form difficult.
The synthetic versions
When added to cell culture, FLAgs were able to substitute for Wnt proteins a hard to source but necessary ingredient in culture mediump; and stimulate the formation of stem cell deriving intestinal organoids; three-dimensional balls of tissue that resemble the small intestine. These 3-D organoids hold great potential for research; and drug discovery but to grow them you need a source of Wnt proteins to activate stem cells.
Most strikingly, when injected into mice, the FLAgs were able to activate the gut stem cells; showing that the antibodies are stable and functional inside the body. The finding raising hopes that FLAgs could be using as treatment for irritable bowel disease; and other ailments to regenerate the intestinal lining when it is damaging.
Treatments for vision loss
Other FLAg variants show promising results in lung, liver and bone regeneration as well as having the potential for treating eye disease. AntlerA has already attracted investment to develop FLAgs into cutting edge therapeutics and is actively working on treatments for vision loss and bowel diseases. The startup’s name was inspired by FLAgs’ geometrical shape which resembles the antlers of deer and moose which are the fastest regenerating organs in animals.
However, the type of discovery we report in our study was possible with a convergence of expertise; says Angers, co-founder of AntlerA. Study were able to apply protein engineering to activate a critical stem cell signaling pathway; with the ultimate goal to develop regenerative medicine promoting the repair of diverse tissues in the body.