p73 is a protein related to the p53 tumor protein. Because of its structural resemblance to p53, it has also been considered a tumor suppressor. Study finding that p73 is requiring for the timely healing of cutaneous wound.
In normal tissue, p73 expression increasing in response to wounding; whereas p73 deficiency resulting in delaying wound healing, they reporting in the journal PLOS ONE. p63 is a transcriptional regulator of ectodermal development; that is requiring for basal cell proliferation and stem cell maintenance.
Wound healing factor
The delay in healing in p73-deficient mice was accompaning by increasing levels of biomarkers of the DNA damage; response in basal keratinocytes at the epidermal wound edge.
They also finding that p73 was expressing by epidermal and hair follicle stem cells; which are requiring for wound healing. Further, they discovering that p73 isoforms expressed in the skin enhance p63-mediating expression of keratinocyte genes during cellular reprogramming from a mesenchymal to basal keratinocyte-like cell.
In wild-type mice, this same cell population exhibited increased p73 expression after wounding. Further, we found that p73 was expressing by epidermal and HF stem cells, which regulate wound healing.
Cutaneous wounds healing
The study establishes a role for p73 in cutaneous wounds healing through regulation of basal keratinocyte function. p73 is requiring for timely cutaneous wound healing in mice. p73 mice exhibited delaying wound healing; due in part to decreased proliferation and increased activation of the DNA damage response in basal keratinocytes at the epidermal wound edge.
Adult tissue stem cells have an important role in tissue maintenance and regeneration after injury. The stem cell function of these long-lived cells decreases with age due to the accumulation of cellular damage; and contributes to the declining functional capacities observed in aging tissues.
Moreover, we discovered that p73 isoforms expressed in the skin (ΔNp73); enhance p63-mediated expression of keratinocyte genes during cellular reprogramming from a mesenchymal to basal keratinocyte-like cell.