Restricting Blood Glucose Levels Might Also Keep Certain Cancers At Bay

According to the preclinical research study; suggesting that anti-cancer effect of keto diet. By keeping blood glucose levels in check can help individuals avoid or manage diabetes. These finally suggesting that restricting blood glucose levels might also keep certain cancers at bay. Researchers restricting circulating glucose in mice with lung cancer.

Circulating glucose restriction was achieved by feeding the mice a ketogenic diet, which is very low in sugar, and by giving them a diabetes drug that prevents glucose in the blood from being reabsorbed by the kidneys. Both the ketogenic diet and the pharmacological restriction of blood glucose by themselves inhibited the further growth of squamous cell carcinoma tumors in mice with lung cancer.

While these interventions did not shrink the tumors, they did keep them from progressing, which suggests this type of cancer might be vulnerable to glucose restriction. While many types of cancer cells are suspected to be heavily dependent on glucose or sugar as their energy supply; Kim and his colleagues have shown in previous laboratory studies that one specific type squamous cell carcinoma is remarkably more dependent than other cancer types, such as adenocarcinoma.

Restricting blood glucose levels

The key finding of our new study in mice; is that a ketogenic diet alone does have some tumor-growth inhibitory effect in squamous cell cancer. When we combining this with the diabetes drug and chemotherapy; it was even more effective. glucose levels in blood samples from 192 patients who had either lung or esophageal squamous cell cancer, as well as 120 patients with lung adenocarcinoma.

The blood samples were taking at random parts of the day; and classified into those containing glucose concentrations higher or lower than 120 mg/dL; which is one clinical measure of diabetes. None of the patients had been diagnosing with diabetes. Manipulating host glucose levels would be a new strategy that is different from just trying to kill cancer cells directly.

Squamous cell carcinoma

Surprisingly, we found a robust correlation between higher blood glucose concentration and worse survival among patients with squamous cell carcinoma; We finding no such correlation among the lung adenocarcinoma patients. This is an important observation that further implicates the potential efficacy of glucose restriction in attenuating squamous-cell cancer growth.

Manipulating host glucose levels would be a new strategy that is different from just trying to kill cancer cells directly. This is part of a paradigm shift from targeting cancer cells themselves. Immunotherapy is a good example of this; where the human immune system is activating to go after cancer cells.