All news from R&D

Alzheimer's, schizophrenia

Shining Lasers on Mouse Brains

Alzheimer’s disease and schizophrenia are some of the most common brain disorders; and have association with problems in cells that contain a type of protein, called parvalbumin. These parvalbumin-containing cells account for almost one-tenth of the cells in your brain, however, relatively little; known about what parvalbumin cells do. By stimulating mouse brains with lasers,…

Social behavior in patients with brain injuries

Animal-assisted Therapy: Improves Behavior in Brain Injuries Patients

Acquired brain injury of traumatic or non-traumatic origins is a globally significant public health issue. It is; estimated that traumatic brain injury annually affects approximately 50–60 million people worldwide; with an incidence rate varying between 50–640/100′000 people per year. Given the high number; of affected people and the consequences of acquired brain injuries; effective therapy,…

Research in mice

Eating Garlic Reduce Aging-related Memory Problems

Consuming garlic helps counteract age-related changes in gut bacteria associated with memory problems; according to a new study conducted with mice. The benefit comes from allyl sulfide; a compound in garlic known for its health benefits. “Our findings suggest that dietary administration of garlic containing allyl sulfide could help maintain; healthy gut microorganisms and improve…

Research in mice

Exercise During Pregnancy: Protects Offspring from Obesity

Accumulating evidences point to the early developmental origins of obesity and its associated metabolic diseases, which are prevalent.  Brown adipose tissue dissipates fatty acids and glucose as heat and; thus, enhancing BAT thermogenic function can effectively prevent obesity and metabolic symptoms. Physical exercise becomes less common in modern societies and moderate exercise during pregnancy is;…

Research in mice

New Way to Tackle Mitochondrial Disease

Mitochondria are highly dynamic double-membrane organelles present in almost all eukaryotic cells. According to recent data, at least 1158 different proteins are; localized in mammalian mitochondria; to ensure a variety of metabolic functions of the organelle. The primary mitochondrial role is to satisfy most of the cellular energy demand; by producing adenosine 5′-triphosphate (ATP) through…

cognition in old mice

Restoring Cognition in Old Mice: Blocking Protein's Activity

By blocking a protein‘s activity with antibodies, Stanford University School of Medicine investigators were able to improve cognitive behavior in aging mice. A paper describing the finding will be published in Nature. Wyss-Coray has been working for several years on the question of; what causes the brain to lose its acuity; with advancing age. One…

A mouse model

In A Mouse Model: Rare Brain Disease Joubert Syndrome

Joubert Syndrome; a ciliopathy associated with mutations in numerous genes encoding cilia components. TALPID3 encoded by KIAA0856 in man; is a centrosomal protein essential for the assembly of primary cilia. Mutations in KIAA0856 have been recently identified in JS patients. Herein, we describe a novel mouse JS model with a conditional deletion of the conserved exons…

Tumor-killing immune cells

Tumor-killing Immune Cells Attack Lymphomas in Living Mice

In a study that will be published in the Journal of Experimental Medicine, researchers from the Institut Pasteur and INSERM reveal that chimeric antigen receptor (CAR) T cells can induce tumor regression by directly targeting and killing cancer cells; uncovering new details of how these immune cells work; and how their effectiveness could be improved;…

'Taste bud cells'

'Taste Bud Cells' in Mice Lungs After Severe Bout of Flu

Most people who weather an infection with influenza fully recover after a week or two. But for some, a severe case of the flu can actually reshape the architecture of their lungs; and forever compromise their respiratory function. With a surprising new finding, researchers from Penn have identified; what they believe to be a major…

Mice examines impact of reused cooking oil

Impact of Reused Cooking Oil: On Breast Cancer Progression

A new study in mice suggests that consuming the chemical compounds; found in thermally abused cooking oil may trigger genetic changes; that promote the progression of late-stage breast cancer. Thermally abused frying oil—cooking oil that repeatedly reheated to high temperatures; may act as a toxicological trigger that promotes tumor cell proliferation; metastases and changes in…

Drug delivery to brains of mice

New 'Pulsing' Ultrasound Technique Improves Drug Delivery

Scientists currently use long-wave pulses of ultrasound to deliver drugs, which can cause side effects. These new findings from Imperial on shorter-wave pulses could have implications for how drugs are used to help patients of Alzheimer’s and other neurological diseases. Neurological diseases like Alzheimer’s can be difficult to treat with drugs because they are often…

Experimental drug

Cholesterol, Obesity-related Nonalcoholic Fatty Liver Disease

Scientists have discovered a novel molecular pathway for an enzyme inhibitor in humans; that plays a direct role in the development of high cholesterol and nonalcoholic fatty liver disease; which they then were able to reverse in mice; with an investigational drug. The study results will be presented at ENDO 2019; the Endocrine Society’s annual…