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Mice born to fathers put on exercise regimen

Mice Born to Fathers Put on Exercise Regimen

Physical exercise is well known for its positive effects on general health; (specifically, on brain function and health), and some mediating mechanisms are also known. A few reports have addressed intergenerational inheritance of some of these positive effects; from exercised mothers or fathers to the progeny; but with scarce results in cognition. We report here…

Study in mice

Study in Mice Uncovers An Unknown Pathway: For Breast Cancer

For many women who thought they had beaten breast cancer, the news that it has roared back years later comes as an especially cruel diagnosis with no clear answers for why or how it recurs. Now a team of Duke Cancer Institute researchers has filled in some critically unknown details that could lead to potential…

mouse study

Scratching The Skin Primes: The Gut for Allergic Reactions to Food

Mast cell (MC) mediator release after crosslinking of surface-bound IgE antibody by ingested antigen underlies food allergy. However, IgE antibodies are not uniformly associated with food allergy, and intestinal MC load is an important determinant. Atopic dermatitis (AD), characterized by pruritis and cutaneous sensitization to allergens, including foods, is strongly associated with food allergy. Tape…

behavioral symptoms

Neuroscientists Reverse: Behavioral Symptoms of Williams Syndrome

Williams Syndrome, a rare neurodevelopmental disorder; that affects about one in 10,000 babies born in the United States, produces a range of symptoms including cognitive impairments, cardiovascular problems, and extreme friendliness, or hypersociability. In a study of mice, MIT neuroscientists have garnered new insight into the molecular mechanisms that underlie this hypersociability. They found that…

muscular dystrophy

Lithium Boosts Muscle Strength in Mice

Standing up from a chair, climbing stairs, brushing one’s hair – all can be a struggle for people with a rare form of muscular dystrophy that causes progressive weakness in the shoulders and hips. Over time, many such people lose the ability to walk or to lift their arms above their heads. This form of…

Research in mice

Sound, Response And Reward Anticipation in Mouse Brain

University of Oregon neuroscientists report that two areas of the mouse brain combine representations of what is heard and anticipated, guiding behavior that leads mice to the best reward.Researchers have known that signals go from the ears to the brain stem, the thalamus and auditory cortex and then onward. What was not; known is how…

Blood pressure drug

Treating Parkinson's And Dementia in Animal Study

A prescribed drug to treat high blood pressure has shown promise against conditions such as Parkinson’s, Huntington’s and forms of dementia in studies carried out in mice and zebrafish at the University of Cambridge. A common feature of these diseases — collectively known as neurodegenerative diseases — is the build-up of misfolded proteins. These proteins,…

In mice

In Mice, Feeding Time Influences The Liver's Biological Clock

The timing of food intake is a major factor driving the rhythmic expression of most genes in the mouse liver, researchers report in the journal Cell Reports. The findings demonstrate that body-wide signals driven by rhythmic food intake significantly contribute to driving rhythms in liver metabolic functions and gene expression independently of the liver and…

insect study

Diet During Development Affects Mating Habits: Insect Study Shows

Theory predicts that the outcome of mating interactions should be; influenced by the condition of both males and females. First, females should base their mating decisions on reliable cues about male quality, which are often condition dependent. Second, the costs and/or benefits of being choosy during mating may depend on the female’s own condition. Finally,…

Research in mice

Growth Hormone Acts to Prevent Weight Loss

Researchers at the University of São Paulo (USP) in Brazil have discovered that growth hormone (GH), which stimulates skeletal maturation and linear bone growth, as well as helping maintain tissue and organs throughout life, also acts directly on the brain to conserve energy when the body loses weight. A paper on the discovery has just…

Protein pileup affects

Protein Pileup Affects: Social Behaviors Through Altered Brain Signaling

Scientists at the RIKEN Center for Brain Science (CBS) have discovered that; when a normal cellular cleanup process disrupted; mice start behaving in ways that; resemble human symptoms of autism spectrum disorder (ASD) and schizophrenia. They found that loss of normal autophagy; the process that recycles damaged cellular components; such as proteins, influences how brain…