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Research in mice

Fasting-mimicking Diet: Treating Inflammatory Bowel Disease

What if a special diet could reduce inflammation and repair your gut? USC researchers provided evidence that a low-calorie “fasting-mimicking” diet has the potential to do just that. Published in Cell Reports, the study reports on the health benefits of periodic cycles of the diet for people with inflammation and indicated that the diet reversed…

Research

TIGER Mouse: Model For Neurological Ailments

New research published in Scientific Reports has devised a way to track tiny message-carriers in the brain that could prove useful in diagnosing and treating injuries, infections or diseases. The study, from assistant professor David Feliciano’s lab in Clemson’s College of Science, uses a glowing mouse—appropriately dubbed the “TIGER mouse—to trace the movement of information-rich…

Research in mouse

Brain Damage In Mouse Models Of Preterm Birth

A research conducted by the INc-UAB shows that; the same perinatal brain injury; caused by hypoxia and ischemia have differentiated effects on each gender; but can be improved through tactile and proprioceptive stimuli. Petting and massaging the mice in the first stages of their life; provided neurological protection in their adult life; especially in male…

Research in mice

Micro-control Of Liver Metabolism

Researchers at TIFR have discovered molecular anticipation of feeding in the liver; that is essential to ensure that the body; after fasting; adapts to utilize incoming nutrients upon re-feeding. Their findings, published in the international journal Cell Reports, show that very small RNA molecules called microRNAs control major metabolic pathways by inhibiting synthesis of proteins,…

Inflammation

High-fat diet & Age: lnflammation In Heart Failure In Mice

Growing older and a high-fat diet enriched with omega 6 fatty acids are major contributors to health risks; ranging from diabetes to heart failure. How these two factors regulate the immune response is not well-understood. Ganesh Halade; and colleagues at the University of Alabama at Birmingham; and other institutions have investigated; how aging and an…

Old mice

CRISPR/Cas9 Therapy Can Suppress Aging In Mice

Aging is a leading risk factor for a number of debilitating conditions, including heart disease, cancer and Alzheimer’s disease, to name a few. This makes the need for anti-aging therapies all the more urgent. Now, Salk Institute researchers have developed a new gene therapy to help decelerate the aging process. The findings, published in the…

Model organism

Model To Study A Lethal Complication

Adult secondary hemophagocytic lymphohistiocytosis (sHLH) is a fulminant hyperinflammatory syndrome with mortality exceeding 80% in spite of state-of-the-art medical care. The pathogenesis of sHLH, unlike primary HLH, which is primarily genetic, is poorly understood. Here we describe a model of sHLH that recapitulates many aspects of human sHLH. Pathogenesis are unknown We found that the…

Research in mice

Decreased Fertility In Female Mice, By Phthalates

A phthalate found in many plastic and personal care products may decrease fertility in female mice, a new study found. Researchers at the University of Illinois found that giving female mice oral doses of the phthalate DiNP for 10 days disrupted their reproductive cycles, decreasing their ability to become pregnant for up to nine months…

HSC in mice

Functional, Transplantable B Cells From Mice: Researchers Generate

Functional B-1 cells derived from mouse embryonic stem cells are capable of long-term engraftment and secrete natural antibodies after transplantation in mice, researchers report in the journal Stem Cell Reports. Scientists have interests in B-1 cells generated from pluripotent stem cells; because they could be tested as a therapeutic for a broad range of immunological disorders.…

Kidney transplantation

Made-to-order Human Kidneys, One Step Closer

The chronic global shortage of donor kidneys leaves many end-stage renal disease patients reliant on continued dialysis treatment. To address the donor kidney shortage, a team led by researchers at the National Institute for Physiological Sciences in Japan attempted to grow mouse kidneys inside rats using transplanted stem cells. The resulting kidneys appeared to be…

Blood flow

In Rats: In Vitro Grafts Increase Blood Flow

Advances in stem cell research offer hope for treatments that could help patients regrow heart muscle tissue after heart attacks; a key to achieving more complete recovery. Scientists today report success in creating functional blood vessels in vitro for hearts of rats that had sustained a heart attack. The journal Nature Communications published the paper, whose lead…

Memory of mice

Brain's Memory Flow: Pinpointing The Controlling Cells

From the cab driver heading for Times Square to the commuter returning home on the freeway, we all carry maps in our head labeled with important locations. And a new Columbia study in mice shows that, by directing the delicate ebb-and-flow of brain activity, a small cluster of cells helps the brain’s internal GPS remember…