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Mouse study

Long-awaited Insights Into Human Stomach Cancer

Mice have been instrumental in the study of cancer; but like all animal models of human diseases, they have their limitations. For stomach cancer in particular; mice have historically been; regarded as quite poor research organisms because; rodents rarely develop spontaneous stomach tumors. But results from a new study are about to shake up the…

Research in mice

Air Pollution Linked To: Reduced Sperm Production In Mice

Exposure to tiny air pollution particles may lead to reduced sperm production, suggests new research in mice to be presented at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La. “Infertility rates are increasing around the world, and air pollution may be one of the main factors,” said lead researcher Elaine Maria Frade…

Research in mice

Intestinal Tumor Growth In Mice: Boosted By High-fructose Corn Syrup

Does sugar directly feed cancers, boosting their growth? The answer seems to be ‘Yes’ at least in mice according to a study. Their study, published in Science, showed that consuming a daily modest amount of high-fructose corn syrup—the equivalent of people drinking about 12 ounces of a sugar-sweetened beverage daily—accelerates the growth of intestinal tumors…

Research in animal

Modified Immune Cells Issue Alert: Detecting Cancer In Mice

Stanford scientists were able to engineer immune cells known as macrophages to detect and flag cancer in mice. The researchers hope the technique can be used for early cancer diagnostics in humans. Immune cells imbued with the power to detect and reveal tumors could be a new method of diagnosing cancer, according to a study from…

Healthy fats in obese mice

Healthy Fats Improve Nerve Function In Obese Mice

Neuropathy is the most common complication of prediabetes and diabetes and presents as distal-to-proximal loss of peripheral nerve function in the lower extremities. So, neuropathy progression and disease severity in prediabetes and diabetes correlates with dyslipidemia in man and murine models of disease. Moreover, Dyslipidemia is characterized by elevated levels of circulating saturated fatty acids…

Mice eyesight

Single Gene Insertion, Blind Mice Regain Sight

It was surprisingly simple. University of California, Berkeley, scientists inserted a gene for a green-light receptor into the eyes of blind mice and, a month later, they were navigating around obstacles as easily as mice with no vision problems. They were able to see motion, brightness changes over a thousandfold range and fine detail on…

Research in mice

Green Tea Cuts Obesity, Health Risks In Mice

Green tea cut obesity and a number of inflammatory biomarkers linked with poor health in a new study. Mice fed a diet of 2 percent green tea extract fared far better than those that ate a diet without it, a finding that has prompted an upcoming study of green tea’s potential benefits in people at high…

Research in mice

Process For Classifying Neurons In Mouse Brain

It’s been estimated that the human brain contains roughly 100 billion neurons; together completing countless tasks through countless connections. So how do we make sense of the roles each of these neurons play? As part of the United States BRAIN Initiative, scientists from Cold Spring Harbor Laboratory (CSHL) have outlined a way to classify neurons…

Research in mice

PTSD-like Behavior At Bay In Female Mice

More than 30 years ago, scientists discovered that neurological illnesses such as mad cow and Creutzfeldt-Jakob diseases are caused by misfolded proteins called prions. But in recent years, Nobel laureate Eric Kandel, MD, demonstrated in mice that some prions are beneficial and serve important biological functions in the brain and body. And today, new Columbia…

Research in mice

Neutralizing Antibodies: Small Molecule Mimics Broadly

Many of us rely on seasonal vaccines for protection against influenza and are only too aware of their limited breadth. Broadly neutralizing antibodies (bnAbs); that target the conserved hemagglutinin (HA) stem of the influenza virus; provide hope for the development of universal vaccines; and are being evaluated in clinical trials. Van Dongen et al. selected…

An animal model

Mouse Model Validates Acne

Researchers have long believed that Propionibacterium acnes causes acne. But these bacteria are plentiful on everyone’s skin and yet not everyone gets acne, or experiences it to the same degree. Genetic sequencing recently revealed that not all P. acnes are the same — there are different strains, some of which are abundant in acne lesions and some that…

BRAIN

Alzheimer’s-like Symptoms In Mice: Diet Reverses

A diet containing compounds found in green tea and carrots; reversed Alzheimer’s-like symptoms in mice genetically programmed to develop the disease; USC researchers say. Researchers emphasize that the study; recently published in the Journal of Biological Chemistry, was in mice; and many mouse discoveries never translate into human treatments. Nevertheless, the findings lend credence to…