Alzheimer's Drug Reverses The Brain Damage In Rats

Research study revealing that the Alzheimer’s drug; reversing brain damage in rats exposing to alcohol during adolescence. By drug using to slow cognitive decline in adults with Alzheimer’s disease; appearing to the reverse brain inflammation; and the neuron damage in rats exposing to alcohol during adolescence.

Then researchers sought to understanding how intermittent binge drinking changes the hippocampus a region long known to be critical for learning and memory; and also linking to anxiety and whether the drug, donepezil, could reverse those changes. Rats were using as a model for teens; and young adults who binge drink a few times a week.

Studies in animal models show that adolescent alcohol exposure can change the ways nerve cells communicate with each other; and the level of plasticity in brain circuits compromising the ability of the brain to change and adapt. These changes can be seeing in adulthood long after the alcohol exposure has ending.

The Alzheimer’s drug

Because they can’t ethically have young people drink alcohol to study its effects; researchers use the developing brains of rats to understand the effects of intermittent alcohol exposure; resulting in blood-alcohol levels that are consistent with those achieved by human adolescent drinkers. Once the rats reaching adulthood, they were giving donepezil; a cognition enhancing drug that is marketing under the brand name Aricept.

After four days of treatment, the researchers studied the animals’ brains, looking closely at the hippocampus. The rats that received donepezil in adulthood after adolescent alcohol exposure showing less inflammation; and better ability to produce new neurons compared to rats that did not receive the donepezil treatment.

Alcohol effecting by donepezil

This  do not know if the reversal of these alcohol effecting by donepezil is permanent; but it at least transiently reverses them. Swartzwelder saying the study helps clarify the subtle health risk of heavy drinking among young adults, which has been difficult to ascertain. It is obvious that not everyone who drinks during adolescence grows up and completely fails at life.

But this might not notice the deficits in obvious ways every day; but you run the risk of losing your edge. Sometimes a small impairment of brain function can have a broad ripple effect in someone’s life. Importantly, the research demonstrates the potential to repair some types of damage caused by adolescent alcohol exposure. But beyond that, it could also lead to a more specific understanding of the cellular mechanisms; that make the developing brain particularly vulnerable to substances such as alcohol.