A molecular classifier based on RNA-sequencing data from transbronchial lung biopsies can recognize; an expression signature associated with usual interstitial pneumonia (UIP) the defining pathology of idiopathic pulmonary fibrosis (IPF). “Diagnosis of interstitial lung disease is frequently by delay, misdiagnosis, use of costly and invasive procedures, and high use of health-care resources,” Dr. Ganesh Raghu…
QUT pharmaceutical scientist Dr. Nazrul Islam, from School of Clinical Sciences, said lung cancer was one of the most common cancers globally and one of the deadliest, being a leading cause of cancer deaths. They says chitosan had long been investigate for drug delivery and medical applications. It is made from refined crustacean (prawns, crabs, lobster)…
Relapse of disease following conventional treatments remains one of the central problems in cancer management, yet few therapeutic agents targeting drug resistance and tolerance exist. New research conducted at the Cancer Center at Beth Israel Deaconess Medical Center found that a microRNA; hence a small fragment of non-coding genetic material that regulates gene expression mediates…
Dietary fibre may be a new tool in the prevention of progressive lung disease, thanks to the production of anti-inflammatory short chain fatty acids (SCFA), according to a new study by Australia’s Priority Research Centre for Healthy Lungs at University of Newcastle, and the Centre for Inflammation, a partnership between The University of Technology Sydney…
Lung cancer, also known as lung carcinoma, is a malignant lung tumor by uncontrolled cell growth in tissues of the lung. This growth can spread beyond the lung by the process of metastasis into nearby tissue or other parts of the body. Most cancers that start in the lung, known as primary lung cancers, are carcinomas. The two main types are small-cell lung carcinoma (SCLC) and non-small-cell…
An international research team led by Nanyang Technological University, Singapore (NTU Singapore); has found that patients with the lung disease bronchiectasis also often display sensitivity to airborne allergens; has highlighted the particular role that fungi appear to play. Their discovery suggests that doctors should examine bronchiectasis patients for a range of allergies, since the treatment…
The build-up of abnormally thick mucus and the inflammation appear to the initiating cause of damage to the lungs of children with cystic fibrosis (CF), rather than bacterial infections; according to a UNC School of Medicine study published in Science Translational Medicine. The research suggests that doctors might able to delay the onset of lung…
A new approach to the treatment of advanced nonsmall cell lung cancer (NSCLC) has reported showing clinically meaningful responses. The investigational drug savolitinib, a MET inhibitor; was used in combination with osimertinib in patients with advanced NSCLC who had resistance to prior epidermal growth factor receptor (EGFR); tyrosine kinase inhibitors (TKIs) and had acquired MET…
Pulmonary hypertension (PH or PHTN) is a condition of increased blood pressure within the arteries of the lungs. Symptoms include shortness of breath, syncope, tiredness, chest pain, swelling of the legs, and a fast heartbeat. In other words, the condition may make it difficult to exercise. Onset is typically gradual. The cause is often unknown.…
Adding the investigational MET inhibitor savolitinib to the EGFR inhibitor osimertinib (Tagrisso); yielded clinical responses in patients who had EGFR-mutant non-small cell lung cancer (NSCLC) that had developed resistance to prior EGFR-targeted therapies through MET-gene amplification; according to interim results from two expansion cohorts of the phase Ib clinical trial TATTON. “To date, targeted therapy…
Respiratory and cardiovascular disease frequently coexist. Although shared risk factors are common, it has become clear that the association between chronic obstructive pulmonary disease (COPD) and cardiovascular disease is independent of these risk factors; indeed, the relationship between severity of airflow obstruction and cardiovascular disease prevalence. Common lung diseases Patients with some of the most…
Charles Darwin is a father of evolution; describing how from simple beginnings “endless forms most beautiful and most wonderful” arise. But while his theory describes the origin of species; it does not just apply to animals and plants. It is also true of cancer. Like creatures adapting to survive in their environment; cancers are dynamic…