Preterm infants with respiratory distress syndrome (RDS) face heightened risks of death, critical illness, and prolonged hospitalization, particularly if they progress to develop acute respiratory distress syndrome (ARDS). To our knowledge, this is the first study comparing NHFOV with NCPAP as postextubation; so respiratory support modes in preterm infants with neonatal ARDS; so Ministry of…
Afatinib is a second-generation potent EGFR-TKI that covalently binds to all homo and heterodimers form by the members of the HER family, such as EGFR, HER2, ErbB3, and ErbB4. In both cell-free kinase and cell proliferation assays, afatinib shows much better inhibitory activity on EGFR harboring L858R/T790M mutations compared to first-generation EGFR-TKIs. Research shows that the…
Most lung adenocarcinomas harbor mutations in KRAS gene (32%) and epidermal growth factor receptor (EGFR) (11%), resulting in overactivation of the RAS-RAF-MEK-ERK pathway. Therefore, ERK signaling appears important or critical in at least 30–50% of NSCLC. ERK1/2 is activate by dual threonine and tyrosine phosphorylation of a TxY (threonine-x-tyrosine, TEY) motif by the mitogen activate…
According to a current study of the Medical University Vienna, specialised T memory lymphocytes in the lungs that react to inhaled allergens, cause attacks of allergic asthma. These T-helper 2-tissue resident memory cells, which are locate in the lungs for a lifetime are know as Th2-TRMs, and are responsible for asthma sufferers having asthma attacks…
A group of respiratory medicine and public health experts are calling for lung cancer in never-smokers to be given greater recognition. Writing in the Journal of the Royal Society of Medicine; so they say that lung cancer in people who have never smoke is under recognize and presents a diagnostic challenge; hence particularly for GPs seeking…
Primary ciliary dyskinesia (PCD) is an autosomal recessive or X‐linked disorder that results from mutations in one or more genes that encode the structural and functional proteins of motile cilia. Notably, PCD leads to abnormal ciliary function. This in turn obstructs mucociliary clearance, causing recurrent and often chronic infections in the upper and lower respiratory…
University of Texas at Dallas scientists have demonstrated that the growth rate of the majority of lung cancer cells relates directly to the availability of a crucial oxygen-metabolizing molecule. In a preclinical study, recently published in Cancer Research, biologist Dr. Li Zhang and her team showed that the expansion of lung tumors in mice slowed…
A deep-learning model developed using serial image scans of tumors from patients with non-small cell lung cancer (NSCLC) predicted treatment response and survival outcomes better than standard clinical parameters. The study is published in Clinical Cancer Research, a journal of the American Association for Cancer Research, by Hugo Aerts, Ph.D. Research demonstrates that deep-learning models…
A short video describing the potential benefits and risks of low-dose CT screening for lung cancer in addition to an informational brochure increase patients’ knowledge and reduced conflicted feelings about whether to undergo the scan more than the informational brochure alone, according to a randomized; so controll trial published online in the Annals of the…
Screening echocardiogram performed at the time of bronchopulmonary dysplasia (BPD) diagnosis can help identify infants at higher risk for developing clinically significant, long-term pulmonary hypertension (PH), particularly when coupled with serum brain natriuretic peptide (BNP) values, according to the results of a retrospective longitudinal study published in Pediatric Cardiology. Bronchopulmonary dysplasia (BPD; formerly chronic lung disease…
Antiepileptic drug (AED) use may increase the risk for pneumonia in patients with Alzheimer disease (AD), according to a study recently publish in the Journal of Alzheimer’s Disease. Alzheimer’s disease (AD), also refer to simply as Alzheimer is a chronic neurodegenerative disease that usually starts slowly and gradually worsens over time. It is the cause of…
A key pathological feature of solid cancer is the massive mobilization and infiltration of immune cells; into the lymphoid organs and the tumor microenvironment. Solid tumors are known for their ability to recruit and modify immune cells endothelial cells which form the tumor microenvironment. A growing body of evidence suggests that host immune cells with…