All news from Pulmonary Medicine

Type 2-High Asthma: Airways at The Single Cell Level Affected

By sequencing genetic material at a cell-by-cell level, researchers have described how type 2-high asthma affects the airways and results in mucus production with more detail than ever before. These findings , which help move forward scientific understanding of the biology behind asthma and could inform the development of targeted treatments for asthma and other airway diseases.

Cystic fibrosis; New Hope Say Experts

A new triple-combination drug treatment being trialed at the Mater Hospital in Brisbane could increase the life expectancy of patients with cystic fibrosisMater Research Institute-University of Queensland (MRI-UQ) researcher Dr. Lucy Burr said these patients were enrolled in Phase 2 of the clinical trial, which aimed at treating the underlying cause of cystic fibrosis.

Severity of Asthma Symptoms Linked to Excessive Airway Nerves, Study

A new study implicates the remodeling of nerves in the airways as a key contributor to heightened sensitivity and airway constriction in patients with asthma. The results provide new insight into a little-understood factor in the development of asthma, a condition that affects about 235 million people worldwide. The study is the first to demonstrate that inflammatory cells can alter nerve structure in the lungs to cause disease.

Life-Threatening Respiratory Disease in Burn Patients: Three factors Aid in Prediction

For the first time, researchers have devised a model to predict burn patients who are most likely to develop life-threatening acute respiratory distress syndrome (ARDS). The prediction model includes three factors: the extent of the patient's inhalation injury, the percentage of the patient's body that was burned and whether the patient had high levels of a blood clotting protein called von Willebrand factor.

KRAS-driven lung cance: A Potential Approach For Cure

The previous decade has seen dramatic advances in the treatment of non-small cell lung cancer, as genes driving subtypes of the disease including EGFR, ALK, ROS1 and BRAF are paired with drugs that silence their action. However, a major genetic driver of non-small cell lung cancer is still without a targeted treatment.

The gene KRAS is known to be amplified in about 25% of non-small cell lung cancers (NSCLC) and despite over 10,000 studies related to KRAS listed in the PubMed database and just shy of 500 clinical trials including the search term KRAS at ClinicalTrials.gov, no successful drugs targeting KRAS are in clinical use.

More Details on Asthma, Causes and Suspects

Asthma is a chronic inflammatory disease of the lungs where the airways become so obstructed the sufferer struggles to breathe. It's vastly more prevalent in Western societies, and usually develops in childhood. But what do we know about what causes it?