Improvement In The Overall Health Of COPD Patients

COPD Patients; The overall efficacy and safety profile of erdosteine is superior to other commonly used mucolytic agents for the treatment of chronic obstructive pulmonary disease(COPD), a new study shows. The study, “Efficacy and safety profile of mucolytic/antioxidant agents in chronic obstructive pulmonary disease: a comparative analysis across erdosteine, carbocysteine, and N-acetylcysteine,” was published in the journal Respiratory Research.

Standard treatment for COPD includes mucolytic agents, which help reduce the viscosity (thickness) of bronchial and lung secretions by breaking down mucus, improving lung function. Studies have shown that mucolytic agents reduce the risk of acute exacerbations (a sudden worsening of COPD symptoms), and lead to an improvement in the overall health of COPD patients.

Team analyze for COPD patients

Common mucolytic agents for COPD treatment include erdosteine, carbocysteine, and N-acetylcysteine (NAC). But there have been no studies comparing the effectiveness of these mucolytic agents. Thus, there is no data to support the use of one agent over another in the treatment, of COPD. To address this issue, researchers perform a meta-analysis to compare the efficacy and safety of 600 mg/day of erdosteine; so to 1,500 mg/day of carbocysteine, and 1,200 mg/day of NAC in the treatment of COPD.

Researchers evaluated the effectiveness of these mucolytic agents; which on the number of acute exacerbations of COPD (AECOPD), duration of AECOPD; and also rates of hospitalization because of  AECOPD. Researchers also investigated the therapies’ safety by looking at the frequency of adverse events (AEs) reported. The team analyzed data from 2,753 COPD patients; so enrolled in seven clinical trials, published between 2004 and 2017.

Use of mucolytic agents

Overall, results show that the use of mucolytic agents was with a significant reduction in the risk of AECOPD. When looking at results from particular agents, researchers found that erdosteine was the most effective, follow by carbocysteine, then NAC. Of note, erdosteine was the only therapy that was with a reduction in the risk of experiencing at least one AECOPD; hence as well as a decrease in the risk of hospitalization due to AECOPD. Furthermore, erdosteine and NAC, but not carbocysteine, significantly reduce the duration of AECOPD.

The AEs cause by erdosteine, carbocysteine, and NAC were all mild, and largely well-tolerated. Base on the results, the team conclude that “the overall efficacy/safety profile; which of erdosteine is superior to that of both carbocysteine and NAC,” they said. The researchers emphasized, however, that “future head-to-head studies perform on the same COPD populations are need to definitely confirm the results of this meta-analysis.”