Pain signaling

Pain signals can travel as fast as touch signals, according to a new study from researchers at Linköping University in Sweden; Liverpool John Moores University in the U.K., and the National Institutes of Health (NIH) in the U.S. The discovery of a rapid pain signaling system challenges our current understanding of pain.

It has until now been believe that nerve signals for pain are always conduct more slowly than those for touch. The latter signals; which allow us to determine where we are being touch, are conduct by nerves that have a fatty sheath of myelin that insulates the nerve. Nerves with a thick layer of myelin conduct signals more rapidly than unmyelinated nerves. In contrast; the signaling of pain in humans has been thought to be considerably slower and carry out by nerves that have only a thin layer of myelin, or none at all.

To answer this, the scientists used a technique that allowed them to detect the signals; in the nerve fibres from a single nerve cell. They examined 100 healthy volunteers and looked for nerve cells that conducted signals as rapidly as the nerve cells that detect touch; but that had the properties of pain receptors, otherwise known as nociceptors.

Pain-signaling system

Pain receptors are characterize by the ability to detect noxious stimuli; such as pinching and abrasion of the skin, while not reacting to light touch. The researchers found that 12 % of thickly myelinated nerve cells had the same properties as pain receptors; and in these nerve cells the conduction speed was as high as in touch-sensitive nerve cells.

The next step was to determine the function of these ultrafast pain receptors. By applying short electrical pulses through the measurement electrodes; they could stimulate individual nerve cells. The volunteers described that they experienced sharp or pinprick pain just as fast as the system that signals touch. The scientists wondered whether such a system is also present in humans.

“The ability to feel pain is vital to our survival, so why should our pain-signaling system be so much slower than the system used for touch, and so much slower than it could be?” asks Saad Nagi, principal research engineer of the Department of Clinical and Experimental Medicine and the Center for Social and Affective Neuroscience (CSAN) at Linköping University.

Various rare neurological conditions

The research team also investigated patients with various rare neurological conditions. One group of people had, as adults, acquired nerve damage that led to the thickly myelinated nerve fibres being destroy, while the small fibres were spared. These patients cannot detect light touch. The scientists predicted that the loss of myelinated nerve fibres should also affect the rapidly conducting pain system they had identified.

It turned out that these people had an impaired ability to experience mechanical pain. Examination of patients with two other rare neurological conditions gave similar results. These results may be highly significant for pain research, and for the diagnosis and care of patients with pain.

“It’s becoming evident that thickly myelinated nerve fibres contribute to the experience of pain when it has a mechanical cause. Our results challenge the textbook description of a rapid system for signaling touch and a slower system for signaling pain. We suggest that pain can be signaled just as rapidly as touch,” says Saad Nagi.