All news from Physiology

B cells

Reducing B Cells With CAR T Cells Is Treatment Lupus

Depleting the number of harmful B cells with novel immunotherapy that employs modified T cells may offer an effective strategy to treat lupus; according to a new study funded by the Lupus Research Alliance. These findings offer a renewed optimism for the elimination of B cells to provide a therapeutic option in lupus and pave…

Sleep loss

Longer Shifts Do Not Create Chronic Sleep Loss

When medical residents were permitted to work shifts longer than 16 hours; patient mortality was not affected and the doctors themselves did not experience chronic sleep loss; according to a pair of papers published today in the New England Journal of Medicine. The study that resulted in the papers follows a 2011 change imposed by…

Weekend sleep

The Weekend Sleep Can Repair From A Week Of Sleepless Nights?

On some health measures; trying to play catch-up for a few days and then returning to poor sleep habits makes things worse. “Their findings suggest that the common behavior of burning the candle during the week and trying to make up for it on the weekend is not an effective health strategy,” says Kenneth Wright,…

Sleeping

Persists Despite Sleeping In Late On Weekends

Many people go without sleep for days and think they can make it up by waking late on the weekend. However, this just makes things worse; according to a new study at the University of Colorado Boulder. Their findings suggest that the common behavior of burning the candle during the week; trying to make up…

Sleep

Sleep Index May Predict Success Of Spontaneous Breathing Trial

Critically ill patients are more likely to successfully weaned from a mechanical ventilator or breathing machine if they have higher levels of wakefulness and both their right and left brains experience the same depth of sleep, according to new research published online. In “Sleep and Pathological Wakefulness at Time of Liberation from Mechanical Ventilation,” Laurent…

Fat cells

Fat Cells Work Different Shifts

Many aspects of mammalian metabolism exhibit daily variation driven in part by an endogenous circadian timing system. This system is comprised of a central ‘master’ clock in the hypothalamic suprachiasmatic nuclei and an integrated network of circadian clocks present in all major tissues within the body. Circadian disruption causes abnormal metabolic physiology. Misalignment of human…

Human Cell Atlas

A Cell Atlas Of The Aging Lung

Aging promotes lung function decline and increases susceptibility to diseases of the respiratory tract. In order to understand these effects in detail; researchers at Helmholtz Zentrum München; a partner in the German Center for Lung Research (DZL), analyzed the aging process in the lung at single-cell level using AI approaches. They have now presented this…

Mitochondrial disorders

Drug May Have Therapeutic Potential In Mitochondrial Disease

New preclinical findings from the extensive cell and animal studies suggest that a drug already used for rare kidney disease; could benefit patients with some mitochondrial disorders complex conditions with severe energy deficiency for which no proven effective treatments exist. Future clinical research is needed to explore whether the drug; cysteamine bitartrate; will meaningfully benefit…

People exercise

Exercise In Morning Or Afternoon To Shift Your Body Clock

Exercise can shift the human body clock; with the direction and amount of this effect depending on the time of day or night in which people exercise. That’s according to new research published in The Journal of Physiology. These findings suggest exercise could counter the effects of jet lag; shift work; and other disruptions to the…

Retina

Retinal Metabolism To Impair Visual Function

How is a healthy retina cell like a tumor cell? It hijacks an energy-producing chemical reaction to churn out molecular building blocks. When tumor cells do it, they use the building blocks to make cancer grow and spread. But when retina cells do it, they renew photo-receptor membranes that keep our vision sharp. West Virginia…

Cell

Spectrum's Ultra-Fast Digitizer Enables Breakthrough In Cell

Cell sorting plays a fundamental role in molecular biology, pathology; immunology and virology research. It requires the ability to rapidly search through and sort out cells based on their unique chemical features and shapes. Conventional methods are limit in uncovering these differences, or are too labor or time intensive; or have to the tradeoff between…

Cells

New Step In Decoding Cell-To-Cell Communication

Cells in our bodies have the ability to speak with one another much as humans do. This communication allows organs in our bodies to work synchronously; which in turn, enables us to perform the remarkable range of tasks we meet on a daily basis. One of this mean of communication is ‘tunneling nanotubes’ or TNTs.…