Exercise May Reduce Artery Stiffening Associated With Heart Failure

New research suggests exercise may prevent or lessen artery stiffening associated with heart failure by limiting the buildup of unsafe chemicals around the heart. The first-of-its-kind study is published ahead of print in the Journal of Applied Physiology. Stiffening in large arteries throughout the body is common in people with heart failure; but less is know regarding this process in the heart’s blood vessels.

Arterial stiffness stems from a number of factors, including reduced elastin (an elastic-like protein in connective tissues) and the buildup of a harmful compound called advanced glycation end products (AGE) that forms when protein or fat combines with sugar in the bloodstream. Previous research suggests that fat tissue surrounding the heart’s arteries (perivascular adipose tissue, or PVAT) plays a role in arterial stiffness-;even in people without heart failure-;because it secretes AGE.

The exercise training

Reducing this stiffness can help preserve blood flow to the heart in people with heart failure. Researchers studied three groups of Yucatan miniature swine with heart failure: One group was sedentary. One group participated in continuous exercise training. One group participated in interval exercise training. Exercise training consisted of treadmill running three days a week for 17 weeks. The continuous group exercised for 45 minutes without stopping plus five-minute warm-up and cool-down sessions.

The interval group alternate between three- and five-minute training periods of different exercise intensity in addition to the warm-up and cool-down. Methods and Results Yucatan mininature swine were divide into four groups: control-sedentary (CON), aortic-banded sedentary heart failure (HF), aortic-band HF continuous exercise train (HF+CONT); also aortic banded HF interval exercise trained (HF+IT). The left circumflex (LCX) and right coronary artery (RCA) underwent ex vivo mechanical testing, and arterial AGE, elastin and collagen were assessed.

Greater AGE secretion

Coronary elastin elastic modulus (EEM) and elastin protein were lower; also AGE was increase with HF compare to CON that was prevent by both HF+CONT and HF+IT. Mouse aortic segments treat with swine coronary PVAT condition media had lower EEM, elastin content; so greater AGE secretion and arterial AGE accumulation in HF compare with CON; which was prevent by both HF+CONT and HF+IT.

Both exercise groups maintain artery elasticity and had lower levels of stiffness than the sedentary group. In addition, the PVAT show less inflammation and release less AGE in the exercise groups. These results “show the efficacy of chronic exercise training as a therapeutic option for treating coronary vascular dysfunction in [heart failure]; so using an intensity tolerable to heart failure patients,” the researchers wrote. Learning more about “the potential of AGE inhibition as a therapeutic strategy to combat arterial stiffness and dysfunction in heart failure is warrant,” the research team said.