To maintain homeostasis, checkpoints must be in place to prevent inappropriate non-canonical inflammasome activation. oxPAPC, a novel Toll-like receptor (TLR4)-independent checkpoint regulator for non-canonical inflammasomes.
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Urechis unicinctus ( U. unicinctus ), a far east specialty food known as innkeeper worm, ethanol extract was studied to examine its potential β-site amyloid cleaving enzyme (BACE) inhibition for the treatment of Alzheimer's disease.
The study described an automated digital microfluidic platform, used to test the functional components of thrombophilia panel on small volumes of plasma with high fidelity, low cost, faster turnover compared with traditional microtiter plate method.
For patients with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy-tropical spastic paraparesis (HAM-TSP), treatment with the humanized anti-CCR4 monoclonal antibody that targets infected cells, mogamulizumab, decreases the number of HTLV-1-infected cells, according to a study published in the journal New England Journal of Medicine.