All news from Pharmacology and Therapeutics

Pharmacology

Comparison Of Three Breast Cancer Drugs Reveals Important Differences

The researches find that the inhibitors showed remarkable efficacy in blocking tumor growth; halting disease progression and boosting survival, leading the FDA to fast-track the approval of three such drugs to date. Today; they are used as frontline medications for patients with advanced, HR+/HER2- Breast cancers. While these drugs have the same biological targets and…

Pharmacology

Comparison Of Three Breast Cancer Drugs Reveals Important Differences

The study find that the patients with the most common form which tests positive for hormone receptors (HR+) and negative for the HER2 receptor usually respond well to treatment. But for those in advanced stages, few treatment options existed until the recent emergence of a new class of drugs known as CDK4/6 inhibitors. These inhibitors…

Pharmacology

Analysis Help Improve Treatment For Merkel Cell Carcinoma Patients

The researches find that the Merkel cell carcinoma (MCC) is a rare, aggressive skin tumor that is diagnosed in approximately 2,000 people each year in the United States. Since MCC affects so few people; it is difficult to study the genetic factors that lead to its development and how those factors correlate with response to…

Pharmacology

Study Finds Alternative To ‘Revolving Door’ Of Opioid Detox And Relapse

The study find that the In a first-ever randomized trial; patients at a short-term inpatient program began long-term outpatient treatment with buprenorphine before discharge; with better outcomes than detox patients. Three out of four people who complete an inpatient opioid withdrawal management program commonly known as “detox” relapse within a month, leading to a “revolving door”…

Pharmacology

Researchers Develop Method For Identifying Aggressive Breast Cancer

The study find that the Precision cancer medicine requires personalized biomarkers to identify patients who will benefit from specific cancer therapies. In an effort to improve the accuracy of predictions about prognosis for patients with breast cancer and the efficacy of personalized therapy, University of North Carolina Line berger Comprehensive Cancer Center researchers have developed…

Biological System That Manages Cells Responsing To The Opioid Drug

Biological System That Manages Cells Responsing To The Opioid Drug

As the researchers finding biological system; that manages cells responsing to the opioid drug exposure. Study discovering a biological system that manages cells’ response to opioid drug exposure. The unexpected discovery offers new ideas for improving the safety of the one of the most effective, and most abused, group of pain medications. Their system relies upon…

Pharmacology

Oral Prostate Cancer Therapies And Pre-Existing Conditions

The study find that  A new large population-based study from the Sidney Kimmel Cancer Center Jefferson Health shows that novel oral androgen signaling inhibitor therapies are associated with an increased risk of death in patients with pre-existing cardiovascular conditions. The research is publish in the journal European Urology. “Data from published clinical trials  reveal a…

Pharmacology

Encapsulating Two Drugs In Same Nanovector Improve Drug Delivery

The study find that the Encapsulating two drugs with different properties into nanovesicles surrounded by antibodies can greatly improve their delivery and efficacy, according to a study led by Xavier Fernández Busquets, director of the joint Nanomalaria unit at the Institute for Bionengineering of Catalonia (IBEC); and the Barcelona Institute for Global Health (ISGlobal), an…

Pharmacology

Blood Flow Is Key To Early Diagnosis And Treatment For People

The study find that the Non-invasive techniques and devices for assessing blood flow and other diagnostic considerations for people with critical limb ischemia are addressed in a new scientific statement from the American Heart Association, published in the Association’s flagship journal Circulation. The statement provides perspective on the strengths and limitations of current imaging techniques,…

Pharmacology

Potential Combination Targeted Therapy For A Deadly Type Of Leukemia

The researches find that the a potential combination targeted therapy for a deadly type of leukemia found in some infants, a population too young to receive full-blown chemotherapy. Called “mixed lineage leukemia (MLL)-rearranged B cell acute lymphoblastic leukemia (B-ALL),” this blood cancer subtype comes with bleak health outcomes (overall survival rate is less than 50%), disease recurrence…

Pharmacology

Medicare Announces Coverage for CAR T-Cell Therapy

The researches find that the Medicare is offering some flexibility in its plan to pay for a costly therapy that involves the re-engingeering of patients’ own cells to fight cancer. The Centers for Medicare & Medicaid Services (CMS); has posted its overdue national coverage decision (NCD) on chimeric antigen receptor T-cell therapy. Therefore This CMS…

Pharmacology

Investigates Potential New Treatments For Pancreatic Cancer

The study find that a new treatment for an aggressive form of pancreatic cancer, which may have the potential to increase the survival of patients resistant to currently available cancer chemotherapeutic drugs. The research; published in the Journal of Experimental and Clinical Cancer Research; found a specialised protein in human pancreatic ductal adenocarcinoma (PDAC) cancer…