All news from Pharmacology and Therapeutics

Potential Anti-Malarial Activity from Peruvian Rainforest Plants

An Atlas-award winning study reported in the Journal of Ethnopharmacology has found that traditional uses of medicinal plants in the Peruvian rainforest are, to a large extent, backed up by science. Samples taken from plants identified by people from the Iquitos-Nauta road communities and studied in the lab have been found to contain extracts that are harmful to protozoan parasites responsible for malaria and other infectious conditions common in the tropics.

Keytruda: Effectiveness Against Advanced Lung Tumors

A cancer drug that boosts the immune system outperforms chemotherapy in fighting advanced lung cancer, a new trial shows. Keytruda (pembrolizumab) extended life four to eight months longer than chemotherapy in lung cancer patients whose immune systems had been duped by their cancer cells.

Drug Efficacy Studies With Aid of Bladder Cancer Model

Understanding that not all bladder cancers are the same, researchers at the University of North Carolina Lineberger Comprehensive Cancer Center have created a tool that may help them to uncover why only a fraction of patients responds to new immune-based treatments.

Salbutamol Doping: Futility of Urine Tests

Salbutamol, also known as albuterol, is a medication that opens up constricted medium and large airways in the lungs and is often used to treat asthma. Because high doses are suspected by some to also have an anabolic effect, its daily dosage is restricted by the World Anti-Doping Agency, which uses urine tests to determine violations. A new British Journal of Clinical Pharmacology study shows that large variability in urine concentrations, however, lead to infeasibility of determining an administered dose from a single untimed urine sample.