All news from Pharmacology and Therapeutics

Study Opens New Therapeutic Avenue For Mitochondria Malfunction

A surprising offender has been emerging to drive the progression of Parkinson's, Alzheimer's, Huntington's and other neurodegenerative diseases: calcium. Calcium controls the production of fuel in mitochondria, the cell's powerhouses. But too much calcium can lead to cellular damage and even cell death. These events can cascade into neurodegenerative diseases and causes injury to the brain and heart during strokes and heart attacks 

Attacking RNA With Small-Molecules Drugs

Yale has developed a way to target RNA with small-molecule drugs, creating a new method for tapping into a vast number of biological mechanisms critical to metabolism and gene expression.

"There is tremendous interest in targeting RNA with small molecules," said Yale biochemist Anna Pyle, whose lab conducted the research. Despite this potential, there has been limited progress on the development of small-molecule drugs that bind RNA, and a pervasive view that RNA is not a viable therapeutic target.

Antifungal Agent used in Porphyria Treatment

A large team of researchers from Spain, France and the U.S. has found that a common antifungal agent might be useful as a treatment for a rare type of porphyria. In their paper published in the journal Science Translational Medicine, the group describes screening thousands of compounds for a treatment for congenital erythropoietic porphyria (CEP)—a rare type of the disease—and what they found.