All news from Pharmacology and Therapeutics

Pharmacology

Cancer Medication Works In Brains Of Parkinson's Patients

Laboratory analysis from the first arm of a phase II clinical trial testing the use of nilotinib in patients with Parkinson’s disease demonstrates precisely how the agent increases levels of dopamine in the brains of study participants, says a research team at Georgetown University Medical Center. Symptoms of Parkinson’s, such as motor dysfunction, are a…

Pharmacology

Medication For Acute Mountain Sickness Does Not Reduce Its Effectiveness

A new study published in Wilderness & Environmental Medicine demonstrated that trekkers and climbers taking a lower dose of acetazolamide (62.5 mg twice daily) were no more likely to develop acute mountain sickness  symptoms than those who took twice that amount, which is the standard prophylactic dose. Side effects. Many trekkers and climbers use acetazolamide to…

Pharmacology

Potential New Target For Chronic Pain Treatment

A research group at Hiroshima University observed a potential new target for chronic pain treatment. Further research using this receptor could lead to new, more effective drugs to use in pain-relieving treatment for chronic pain. Conditions that cause chronic pain can be difficult to manage. Best painkiller These include sciatica, cancer and rheumatoid arthritis. Chronic…

Antibiotics

Common Antibiotic Prescribed For Diarrhea Is Failing

In the world of superbugs (bacteria that has grown resistant to antibiotics) Clostridioides difficile; a bacterium that causes diarrhea and colitis; is among the most stubborn. In 2013 the Centers for Disease Control called C. diff an “urgent threat” after causing 30,000 deaths in 2011. So it is often picked up by patients over 65 who…

Pharmacology

Medication Management Challenges For Home Care Providers

Medically high-risk patients and communication breakdowns between providers contribute to the difficulty of medication management for older adults receiving home health care, finds a study led by researchers at NYU Rory Meyers College of Nursing. The findings are published in the journal Medical Care Research and Review. Initial hospitalization “Our study suggests that medication management coordinated…

Pharmacology

Drug To Treat Schizophrenia Could Be Safely Given To African

A study led by researchers at Cardiff University means that more people of African descent who have treatment-resistant schizophrenia could be safely given the drug best proven to manage their symptoms. The team identified a genetic and benign cause in people of African descent for lower neutrophil levels: a condition that can also be a…

Pharmacology and therapeutics

Lung Cancer Treatment Combo Given Initial NHS 'No' In England

A treatment combination is  provisionally reject for people with certain types of lung cancer on the NHS in England. The decision  is review by the National Institute for Health and Care Excellence (NICE) at the end of March. The combination include four drugs: the immunotherapy atezolizumab, a targeted drug called bevacizumab (Avastin), plus two chemo…

Pharmacology and therapeutics

New Therapeutic Target Found For Aggressive Pediatric Cancers

Researchers at The University of Texas MD Anderson Cancer Center have discovered that malignant rhabdoid tumors , a rare pediatric cancer without effective treatments, may be sensitive to drugs that block the cancer cell’s ability to dispose of misfolded proteins. The findings provide a much-needed therapeutic target for these and other cancers caused by mutations…

Mycobacterium Tuberculosis Bacteria

New Experimental Antibiotic For Tuberculosis

Mycobacterium tuberculosis bacteria reside for longer, killing them more effectively. The research in Antimicrobial Agents and Chemotherapy. The goal of TB drug development programs is to develop universal treatment regimens that will shorten and simplify TB treatment in patients; which typically takes at least six months; and sometimes more than a year, said lead author…

Oral antibiotic therapy

Antibiotic Therapy In Managing Orthopedic Infections

“In this trial, with regard to treatment failure assessed at 1 year; oral antibiotic therapy was noninferior to intravenous antibiotic therapy when used during the first 6 weeks of treatment for bone and joint infection; our results thereby challenge a widely accepted standard of care. “Oral antibiotic therapy was associated with a shorter length of…

Tanezumab

Tanezumab Beneficial Osteoarthritis Pain

Osteoarthritis (OA) is a type of joint disease that results from the breakdown of joint cartilage and underlying bone. The most common symptoms are joint pain and stiffness. Initially, symptoms may occur only following exercise, but over time may become constant. Other symptoms may include joint swelling, decreased range of motion, and, when the back is affected, weakness or numbness of the arms and legs. The most commonly…

Medicine

Impact Drug Development And Personalized Medicine

Medicine is the science and practice of establishing the diagnosis, prognosis, treatment, and prevention of disease. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others. Brain tumor drug A breakthrough for…