All news from Pharmacology and Therapeutics

Pharmacology

New Combination Therapy Found To Be Well Tolerated In Patients

A phase I clinical trial that set out to assess the safety of a new combination therapy for a type of aggressive brain tumor has found the treatment to be well tolerated in patients. Because The trial used a treatment combination of ADI-PEG20, pemetrex and cisplatin; which showed encouraging efficacy in patients with recurrent high-grade…

Pharmacology

Old Antibiotic Shows Promise In Treating Fatal

Of the three major subtypes of breast cancer, the & laquotriple negative» is the most lethal: half of all breast cancer deaths are attributed to it, whereas it accounts for only about 15% of incidences of breast cancer. And unlike other breast cancers, it is resistant to most existing therapies. By studying the properties of…

Pharmacology

Taxane, Platinum Feasible For Adjuvant Tx In Endometrial Cancer

Taxane plus platinum regimens may be a reasonable alternative to doxorubicin plus cisplatin as postoperative adjuvant chemotherapy for endometrial cancer that carries a high risk for progression, according to a study published online March 21 in JAMA Oncology. Hiroyuki Nomura, M.D., from the Keio University School of Medicine in Tokyo, and colleagues evaluated the clinical benefit…

Pharmacology

Symptomatic Pharmacotherapy Of Elderly People

The prevalence of using antidepressants and proton pump inhibitors increases after the diagnosis of Alzheimer’s disease, according to a doctoral dissertation from the University of Eastern Finland. The use of antidepressants is associat with an increase risk of hip fracture among persons with and without Alzheimer’s disease. The use of proton pump inhibitors, however, did…

Pharmacology

Rituximab Added To Chemotherapy Confers No EFS Benefit

Patients with primary central nervous system lymphoma did not benefit from the addition of rituximab to methotrexate-based chemotherapy , according to results of a randomized phase 3 study published in Journal of Clinical Oncology. “Histologically, more than 90% of primary CNS lymphomas are CD20-positive diffuse large B-cell lymphomas,” Jacoline E.C. Bromberg, MD,of the department of neuro oncology at…

Pharmacology

Alternatives For The Treatment Of Schizophrenia

A group of Brazilian scientists have long conducted experiments with roundworms to investigate the role of schizophrenia-linked genes in patients’ response to antipsychotic drugs. The results obtained thus far point to new ways of understanding resistance to certain classes of medication. The studies are conduct by researchers in the Pharmacology Department of the Federal University…

Pharmacology

Development Of New Treatments For Alzheimer's Disease

New research by academics at Royal Holloway, University of London, urges scientists that are looking to finding a cure for Alzheimer’s disease to focus on the role of proteins in the brain that cause Alzheimer’s disease. This change in focus could enable the development of new treatments. Effective treatments. It has long been recognizes that…

Pharmacology

Cholesterol Lowering Drug Also Help Treat Cancer

Brazilian researchers have discovered that a drug regularly prescribed to control cholesterol can also be used to treat cachexia, or wasting syndrome, a condition characterized by rapid weight loss and muscle atrophy associated with extreme physical weakness. This condition is common among patients with chronic diseases such as cancer, heart failure and AIDS. Research Foundation…

Pharmacology

Partial Oral Antibiotic Therapy Shows Efficacy And Safety

Patients with an infection of the inner lining on the left side of the heart (endocarditis) who were switched from intravenous to oral antibiotic therapy had better long-term survival and fewer complications than similar patients who remained on conventional intravenous antibiotic therapy, according to research presented at the American College of Cardiology’s 68th Annual Scientific Session.…

Pharmacology

Life Saving Antibiotic Receives New Use Guidelines

An international panel of the foremost researchers on infectious disease and antimicrobials has formed new guidelines on the use of polymyxins, a class of antibiotics employed as a last resort to treat deadly, drug-resistant bacteria. The guidelines, published last month in Pharmacotherapy, set new standards for the clinical use of polymyxins, including on maximum dosage, treatment strategies…

Pharmacology

New Drug Help Those With Tough To Treat Cholesterol

People whose high cholesterol is resistant to treatment with statin drugs may soon have a new treatment option. This new class of drugs helps block synthesis of artery-clogging cholesterol; researchers explained. The drugs target an enzyme called ATP citratelyase (ACL), part of the production pathway for “bad” LDL cholesterol in the body. Increasing the dose In…

Pharmacology

Researchers Create A New Molecule To Treat Heart Failure

A group of researchers based in Brazil and the United States have developed a molecule that halts the progression of heart failure and improves the heart’s capacity to pump blood. Rats with heart failure are treat for six weeks with the molecule SAMβA. The disease not only stabilized, as it usually does in response to…