Pharmacology

The researches find that a new combination therapy for breast cancer treatment leads to a lowered risk of the disease coming back. A commentary on this landmark clinical trial has been publish in the latest issue of the Journal of Clinical Oncology by the researchers Masey Ross and Charles Geyer Jr. from the VCU Massey Cancer Center. The commentary was titled; “Nab-Paclitaxel:  The modify drug combination is find to be useful in women with a high risk; HER-2 negative breast cancer, the researchers wrote.

The breast cancer treatment

They explain that this group of breast cancer patients are an important subset of breast cancer patients and this makes the study so important. Ross is a medical director of the Integrative Health Program ;and breast medical oncologist at Massey and assistant professor of internal medicine at the ;VCU School of Medicine while Geyer is an associate director for clinical research, Harrigan, Haw; Luck Families Chair in Cancer Research; breast medical oncologist and also a member of the Developmental Therapeutics research program at Massey and a professor of internal medicine at the VCU School of Medicine.

The team explains that at present the standard treatment for breast cancer patients with high risk lymph node negative or positive is neoadjuvant chemotherapy that is given before the surgery. The standard drug used in this situation is Paclitaxel which leads to hypersensitivity or allergic reactions and damage to the nerves. The researchers also said that nerve damage caused ;by paclitaxel is often severe for these HER-2 positive breast cancer patients and prevents them from being administered these agents.

High risk lymph node

This new study by the German Breast Group (GBG); in 2016 used albumin-based drug nab-paclitaxel (Abraxane) as an alternative of standard Paclitaxel before surgery. Nab paclitaxel stands for “Nanoparticle albumin-bound paclitaxel”. Nab-Paclitaxel has been approved for use in advanced metastatic breast cancer since 2005. In the early trials three weekly of therapy with nab-paclitaxel (260 mg/m2 as a 30-minute infusion); was compared with standard paclitaxel at “175 mg/m2 as a 3-hour infusion.” Results had shown that overall response is better with nab-paclitaxel; (33% compared to 19% with standard paclitaxel).

Similarly median time taken for the tumour to progress was 16.9 weeks for standard paclitaxel and 23 weeks for nab-paclitaxel. Phase 3 trials of nab-paclitaxel show that there is a 10% risk of neuropathy ;compared to a 2% risk with standard paclitaxel. They noted that at the time of surgery Abraxane led to pathological response ;(removal of traces of cancer from the breast as well as an adjoining lymph nodes); in the cancer in patients with triple negative breast cancer. Other disease subtypes did not fare as well; the researchers wrote.