Pharmacology

The researches find that the combination Immune Therapy of a vaccine and a medicated cream is a promising strategy to dramatically reduce the recurrence of genital herpes. Therefore Their study; co-led by researchers at the University of Pennsylvania and University of Cincinnati Children’s Hospital Medical Center; was published in the journal npj Vaccines. Herpes simplex virus (HSV) type 2, which causes genital herpes, is very common; affecting more than 400 million people worldwide. But There’s no cure and efforts to develop a vaccine have had limited success.

The combination Immune Therapy

The research team tested a novel vaccine strategy, known as prime and pull; in guinea pigs infected with genital herpes. Because The “prime” involves a vaccine that generates a response to the virus from T cells; highly specialized immune cells. Because The “pull” consists of a cream containing imiquimod; a medication commonly used to treat genital warts. Applied to the affected area, the cream attracts key immune cells to the site of infection where they can block the virus from spreading and causing herpes lesions.

The study showed that the effect of the combination therapy was far greater than either the vaccine or cream alone. “It’s the first time that a study has shown that prime-and-pull strategy can block existing recurrent disease;” said co-corresponding author Akiko Iwasaki, the Waldemar Von Zedtwitz Professor of Immuno biology at Yale School of Medicine. Because “Development of a therapeutic HSV vaccine is a high priority. Our exciting results have encouraged us and; hopefully others, to pursue this strategy with more vaccines;” said co-corresponding author David Bernstein, professor of pediatrics and former director of the Division of Infectious Diseases at Cincinnati Children’s Hospital.

Existing recurrent disease

A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains a small amount of an agent that resembles a microorganism. The agent stimulates the body’s immune system to recognize the agent as foreign, destroy it, and “remember” it; so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters. Vaccines can be prophylactic (e.g. to prevent or ameliorate the effects of a future infection by any natural or “wild” pathogen), or therapeutic (e.g. vaccines against cancer are also being investigated; see cancer vaccine).

The study team gave three rounds of treatment to the animals, noting that the strategy worked rapidly and beginning with the first round. Therefore This strategy, if developed into a therapy for humans, could be a game changer for individuals with recurrent infections or resistance to standard antiviral treatment, said Iwasaki. Active herpes infection causes painful lesions that are physically and emotionally harmful to affected people, she noted