Pharmacology

The researches find that chemotherapy can be very efficient in eliminating cancerous cells; therefore anti-cancer drugs affect normal, healthy cells. Damage to healthy cells causes side effects. In order to avoid the undesirable side effects of the cancer medication, the investigation of synthetic peptides, which is  use as active ingredients in the medication; is very important. Because Peptides (from the Greek πεπτίδια, “small digestibles”) are short polymers form from the linking; in a defined order, of α-amino acids.

Eliminating cancerous cells

The link between one amino acid residue and the next is know as an amide bond or a peptide bond. Because Proteins arepolypeptide molecules (or consist of multiple polypeptide subunits). Because The distinction is that peptides are short and polypeptides/proteins are long. therefore There are several different conventions to determine these; all of which have caveats and nuances. In chemistry, an amino acid is a molecule containing both amine and carboxyl functional groups.

These molecules are particularly important in biochemistry; where this term refers to alpha-amino acids with the general formula H2NCHRCOOH; where R is an organic substituent. In the alpha amino acids; the amino and carboxylate groups are attached to the same carbon atom, which is called the α carbon.

Several different conventions

The various alpha amino acids differ in which side chain (R group) is attache to their alpha carbon. They can vary in size from just a hydrogen atom in glycine through a methyl group in alanine to a large heterocyclic group in tryptophan. Because The team of Lithuanian scientists are aiming to duplicate active ingredients of amino acids found in nature, which would contain heightened active biological effect.

“While building new amino acid molecules it is most efficient to create minimal modifications of the fragments of the natural structure. It means that when the medication contains active ingredients from the natural sources; it can have both targeted and side effect. However; the synthesised modified materials not only help increase biological efficiency but also minimise side effects. The theory is being tested in laboratories”, says Dr. Greta Ragaitė, one of the KTU researchers working on the project.

Contains active ingredients

The team behind the project in KTU, Lithuania is led by Professor Algirdas Šačkus and made up of Dr. Greta Ragaitė, Dr. Neringa Kleizienė, and master’s students Aistė Kveselytė and Urtė Šachlevičiūtė. They recently started to investigate the possibilities to create new selenazole and pyridine fragments containing synthetic amino acids, which could be used to create peptides.
“The almost year-long project bore fruit,” said Dr. Neringa Kleizienė, “They have created building blocks, which will be the ingredients in synthetic peptides that will allow us to create anti-cancer medicine prototypes.” Synthetic peptides could be used to negate the anti-cancer medicine side effects. The newly created material has already received attention from global pharmaceutical giants.