All news from Pathology & Microbiology

Glioblastoma

New Molecule Drug An Effective Strategy To Treat Glioblastoma

Glioblastoma , the most common form of brain cancer, is a deadly disease for which there is no cure. Known for resistance to conventional treatments, such as the chemotherapy drug temozolomide; glioblastoma is the form of cancer that ultimately lead to the recent death of U.S. Senator John McCain. Glioblastoma is the most invasive and…

T-Cells and Pathogens

First Footage of T-Cells Training To Fight Pathogens Revealed

Immunologists at The University of Texas at Austin have recorded visuals of T-cells; but learning what kind of cells to ignore when fighting pathogens; to ensure they do not attack healthy cells and tissues when fighting disease. It is the first time that this process has been captured on video. T-cells are a type of…

Investigation of Cancer

The History Behind The Investigation of Cancer As Contagious Illness

In 1961, people in the suburb of Niles, Illinois, experienced what they termed a “cancer epidemic.” Over a dozen children in the town were diagnosed with leukemia within a short time. Fears quickly spread that the illness could be contagious; carried by some type of “cancer virus.” News coverage soon identified several other towns; but…

Antibodies

‘Inconsistent’ Use Of Antibodies In Lab Experiments

Scientists at the Johns Hopkins Kimmel Center say they have affirmed widespread inconsistencies; but in the use of a common laboratory procedure called immuno-histochemical staining; and say the variations are making many laboratory experiments unreliable. Their findings were outlined in a special issue of the Asian Journal of Urology. In a review of papers published…

Tumors

Profound Insights Into Tumors' Unique Genetic Features

Large libraries of cancer cell lines collections of cells that represent tumor types seen in cancer patients; but can yield profound insights into tumors’ unique genetic features; and their sensitivities to current and potential treatments. The data produced by these libraries is invaluable for developing new therapeutic options for patients. Such is the case with…

Gastric Glands

New Drug Design Might Inhibit Hepatitis A Virus

Structure-based drug design revealed that a compound previously investigated for the treatment of head-and-neck cancer could function as a lead compound for the development of drugs to treat hepatitis A virus infection, according to a study publishing April 30 in the open-access journal PLOS Biology by Dan Su of Sichuan University, Zihe Rao of Tsinghua University, Xiangxi…

Helicobacter pylori

Helicobacter pylori Survives In The Stomach

The stomach-dwelling bacteria Helicobacter pylori survives in the stomach a hellish; churning vat of hydrochloric acid; by holing up inside that organ’s pit-like glands and establishing squatter’s rights. Once the germ has set up shop, Stanford University School of Medicine investigators have learned; but even competing strains of the same species can’t displace it, or even…

Gonorrhea

Drug Combination: Effective For Treatment-Resistant Gonorrhea

The study, funded by the National Institute for Health Research (NIHR); in The Lancet and is the first randomized trial to compare the two treatments for the sexually transmitted infection amid concerns; of growing resistance to ceftriaxone. Public Health England (PHE) recently that it was investigating two cases of gonorrhea in two women with similar…

Cytomegalovirus

New Viral Molecular Evasion Mechanism Used By Cytomegalovirus

A study published in the journal PLOS Pathogens describes a new viral molecular evasion mechanism used by cytomegalovirus to interfere in the immune response of the infected host. The recent study, led by the lecturer Ana Angulo; from the Faculty of Medicine and Health Sciences of the University of Barcelona; and the August Pi i Sunyer…

Infections

United Nations Sounds Alarm Bell On Drug-Resistant Infections

According to a new report from a United Nations Committee, antibiotic resistance levels; but are at an all time high and are the reason behind common infections becoming difficult to treat. The report adds that simple life-saving surgeries are increasingly becoming risky and life threatening because of lack of post operative effective antibiotic coverage. The…

Superbug

Superbug Evades The Immune System To Cause Infection

New research led by the University of Sheffield has discovered how a hospital superbug; evades the immune system to cause infection – paving the way for new treatments. The study, led by the University of Sheffield’s Department of Molecular Biology and Biotechnology, investigated how Enterococcus faecalis (E. faecalis), bacteria commonly found in the digestive tracts…

Antimicrobial Dosing Regimens

Evolution And Ecology Inspire Antimicrobial Dosing Regimens

Taking an evolutionary view can inspire new ideas in clinical microbiology. For example, evolutionary studies can reveal why some antimicrobial dosing regimens; but are better than others in preventing the development of drug resistance. Looking at microbial communities, rather than just pathogenic micro-organisms, can also lead to new insights. That is why clinicians, bioinformaticians analysing…