All news from Pathology & Microbiology

Air Pollution in Mexico Linked with Alzheimer's Pathology

A new study by researchers at the Universities of Montana, Valley of Mexico, Boise State, Universidad Veracruzana, National Institute of Pediatrics and Paul-Flechsig-Institute for Brain Research heightens together with German company Analytica Jena concerns about the evolving and relentless Alzheimer's pathology observed in young Metropolitan Mexico City (MMC) urbanites. These findings are published in the Journal of Alzheimer's Disease .

The New Way To Cut The Power Of Tumors

Instead of tackling tumors head-on, an international team of researchers from the University of Geneva (UNIGE) and the Amsterdam UMC, location VUmc in Amsterdam has chosen to regulate their vascularization by intervening with the cellular receptor that is explicitly overexpressed in tumor blood vessels.

Increasing Prevalence Of Antibiotic Resistance

Researchers found that a low-intensity use of antibiotics may play more than one role in antibiotic resistance than high-intensity, repeated use by a small fraction of the population

The increasing prevalence of antibiotic resistance in the United States appeared more closely related to their occasional use according to many people than to their repeated use among smaller numbers of people, according to Harvard TH Chan School of Public Health.

Insights into Pathology of Dwarfism May Lead to New Treatment Targets

Pseudoachondroplasia (PSACH) is a severe inherited dwarfing condition characterized by disproportionate short stature, joint laxity, pain, and early onset osteoarthritis. In PSACH, a genetic mutation leads to abnormal retention of cartilage oligomeric matrix protein (COMP) within the endoplasmic reticulum (ER) of cartilage-producing cells (chondrocytes), which interferes with function and cell viability.

In a report in the American Journal of Pathology, investigators describe how this protein accumulation results in "ER stress" and initiates a host of pathologic changes. These findings may open up new ways to treat PSACH and other ER-stress-related conditions.

Rise in Hospital Mortality with Drug Resistant Infections: Indian Study

In one of the most expensive studies to measure the burden of antibiotic resistance in a low- or middle-income country, researchers at the Center for Disease Dynamics, Economics & Policy report that in-hospital mortality is significantly higher among patients infected with multi-drug resistant (MDR) or extensively drug resistant (XDR) pathogens including Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii.

HSV-1 qPCR in the Diagnosis of Lower Respiratory Tract Infections

Researchers aimed to determine a quantitative herpes simplex virus (HSV) DNA threshold in lower respiratory tract specimens that correlates with positive viral culture and clinical outcomes. In this study, researchers determined a quantitative threshold of HSV DNA in lower respiratory tract specimens that correlated with positive viral culture and clinical outcome.

Researchers also investigated the utility of quantitative polymerase chain reaction (qPCR) for a housekeeping gene to account for differences in the cellularity of the lower respiratory tract specimens. Finally, we evaluated the relationship between the HSV viral load and clinically relevant outcomes.