MIT cancer biologists have discovered a new mechanism that lung tumors exploit to promote their own survival: These tumors alter bacterial populations within the lung, provoking the immune system to create an inflammatory environment that in turn helps the tumor cells to thrive. This study was published in Cell. Bacterial burden: lung to lung cancer development…
All news from Pathology & Microbiology
Research on the gut metagenome of patients with Crohn’s disease elucidates how it influences the taxonomic and functional composition of intestinal microbiota. Among the most common changes are the decrease in the diversity of beneficial microbes and the increased abundance of Escherichia coli and other microbes associated with inflammation. The results can help to better understand the…
A bacterium seems to cause Alzheimer’s as well as gum disease. It’s hinting that our microbial denizens has involvment in many diseases we thought weren’t infectious. The suggestion that a bacterium behind gum disease could be the long-elusive cause of Alzheimer’s. It is an early contender for most astounding science story of the year. The…
Emerging infectious diseases comprise a substantial fraction of important human infections, with potentially devastating global health and economic impacts. A 2008 paper in Nature described the emergence of no fewer than 335 infectious diseases in the global human population between 1940 and 2004.
One of the major issues when studying ore deposits formed in surficial or near-surface environments is the relationship between ore-forming processes and bacteria. At a first glance, these environments appear to be a preferred place for the growth of microbial ecosystems because they potentially have large amounts of nutrients. However, studies have been restricted because of the low likelihood of microbe fossilization and because biomarkers are not always definitive.
Less than two years after the first report of wild chimpanzee in Uganda dying as a result of a "common cold" virus, a new study has identified two other respiratory viruses of human origin in chimpanzee groups in the same forest. Writing this week in the journal Emerging Microbes and Infections , a team led by Tony Goldberg, an expert on emerging pathogens in animals, describes two simultaneous outbreaks of respiratory illness in chimpanzees in the wild, one of which was lethal. Goldberg is also associate director for research at UW-Madison's Global Health Institute.
New science uncovers how an unlikely culprit, Porphyromonas gingivalis (Pg) — the bacterium commonly associated with chronic gum disease — appears to drive Alzheimer's disease (AD) pathology. A paper published in Science Advances details how researchers identified Pg in the brains of patients with AD.
Do the same laws of biodiversity which apply in nature also apply to our own bodies and homes? If so, current hygiene measures to combat aggressive germs could be, to some extent, counterproductive. So writes an interdisciplinary team of researchers from iDiv in the journal Nature Ecology & Evolution. They propose that examination of the role diversity of microorganisms plays in the ecosystems of our bodies and homes should be intensified.
APC Microbiome Ireland scientists based at University College Cork have shown for the first time that a high fat "western" diet reduces the efficiency of the immune system to fight infectious disease particularly in the gut, and to infection with the foodborne pathogen, Listeria monocytogenes. The researchers found that feeding mice with a "westernised" diet, which is high in fat and low in fermentable fibre, affected both the immune system and the bacteria resident in the gut (the gut microbiota).
Clostridium difficile infection (CDI) is a potentially deadly infection in the large intestine most common in people who need to take antibiotics for a long period of time, particularly in Australia's ageing population. But when doses of a new antibiotic called Ramizol were given to hamsters infected with a lethal dose of the bacteria, a significant proportion of hamsters survived the infection. The research was recently published in journal Scientific Reports.
Fecal-microbiota transplantation (FMT) is superior to 10 days of fidaxomicin or vancomycin for resolving recurrent Clostridium difficile infection (CDI), according to results from a randomized open-label clinical trial. The researchers report in Gastroenterology.
Researchers at the Medical University of South Carolina (MUSC) studying osteoimmunology, the interface of the skeletal and immune systems, have examined the impact of disrupting the healthy gut microbiome with antibiotics on post-pubertal skeletal development. Their results, published online in the American Journal of Pathology, showed that antibiotic disruption of the gut microbiota induced a pro-inflammatory response that led to increased activity of osteoclasts.